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Integrative neuroinformatics to relate genomics to neurocircuitry and psychopathology

Award Number: K01MH108721
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/01/2016
PERIOD OF PERFORMANCE END DATE: 03/31/2020

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Integrative neuroinformatics to relate genomics to neurocircuitry and psychopathology - Modified Project Summary/Abstract Section Corrected Panatzatos Identification and characterization of genomic factors involved in maintaining brain circuits and neurotransmitter systems associated with psychopathological behavior could identify new therapeutic targets and elucidate mechanisms of psychopathology. Using recently available human postmortem brain gene expression maps (Allen Brain Atlas) and methods to quantify large-scale in vivo functional connectivity (FC) from fMRI data, the proposed project will develop and validate new computational tools which relate functional network architecture to molecular neuroanatomy in order to identify and characterize genomic risk factors for major depressive disorder (MDD) and suicide. Our pilot data demonstrate correlations between gene expression and FC, suggesting sufficient inter-individual consistency in their spatial distributions to allow detection of genes whose expression predict FC. Separate streams of research have linked abnormalities in FC related to resting state and negative valence processing to MDD and suicidal behavior. Dysregulated genomic factors that are involved in these specific circuits are more likely to confer risk towards these disorders. Aim 1 is to develop and validate computational approaches that identify genes whose expression predict FC associated with resting state and negative valence processing. Aim 2 is to test whether these genes are also dysregulated in MDD and suicide using a distinct genomics dataset, which would suggest translational value for the approach developed in Aim 1. A Corollary Aim is to create publically available, open-source tools which can be applied to identify genomic factors related to other RDoC constructs using task and resting-state fMRI. It is anticipated this project will facilitate evidence-based identification of psychiatric biomarkers and hypothesis generation. Results would also elucidate the relationships of genes with neural circuits and psychopathology at the NIMH Research Domain Criteria (RDoC) level and further our understanding of the molecular biology of brain functional architecture, mood disorders and suicidal behavior. To carry out these aims and attain my career goal of becoming an expert in translational neuroinformatics, the PI has mapped out a course of further training in clinical and molecular neuroscience, computational genomics, computer science and informatics and advanced statistics. This training will complement and build upon the PI’s previous training in cellular physiology, cognitive neuroscience and computational neuroimaging.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2020 ( Subtotal = -$787 )
2020	2019	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	4	9/3/2020	NON-COMPETING CONTINUATION	-$787
														Subtotal = -$787

Issue Date FY: 2019 ( Subtotal = $184,867 )
2019	2019	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	4	3/13/2019	NON-COMPETING CONTINUATION	$184,867
														Subtotal = $184,867

Issue Date FY: 2018 ( Subtotal = $184,867 )
2018	2018	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC.	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	3	3/20/2018	NON-COMPETING CONTINUATION	$184,867
														Subtotal = $184,867

Issue Date FY: 2017 ( Subtotal = $184,867 )
2017	2017	RESEARCH FOUNDATION FOR MENTAL HYGIENE INC	1051 RIVERSIDE DR	NEW YORK	NY	10032	NEW YORK	USA	Mental Health Research Grants	000	2	3/3/2017	NON-COMPETING CONTINUATION	$184,867
														Subtotal = $184,867

Issue Date FY: 2016 ( Subtotal = $184,867 )
2016	2016	RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC	150 BROADWAY SUITE 301	MENANDS	NY	12204	ALBANY	USA	Mental Health Research Grants	000	1	3/30/2016	NEW	$184,867
														Subtotal = $184,867

Grand Total All Awards = $738,681

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Integrative neuroinformatics to relate genomics to neurocircuitry and psychopathology

Award Number: K01MH108721

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/01/2016

PERIOD OF PERFORMANCE END DATE: 03/31/2020

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