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Sleep Duration During Pregnancy and the Risk of Postpartum Depression

Award Number: K01MH085976
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 06/07/2010
PERIOD OF PERFORMANCE END DATE: 05/31/2014

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Sleep Duration During Pregnancy and the Risk of Postpartum Depression - DESCRIPTION (provided by applicant): To meet the demands and opportunity of our modern society, sleep curtailment is common among many Americans. Women now occupy a more prominent place in the work force without reducing most of the responsibilities at home. Many women struggle to balance family and work demands. Consequently, sleep needs are often pushed to the bottom of women's daily priority list. Prior research has indicated that short sleep duration is associated with higher levels of pro-inflammatory serum cytokines, which are associated with postpartum depression. However, few research studies have directly examined the relationship between sleep duration during pregnancy and postpartum depression. The proposed study aims to address the gaps in our knowledge and understanding of sleep duration during pregnancy and its effects on preterm delivery and postpartum depression. We hypothesize that shorter sleep duration during pregnancy increases the risk of spontaneous preterm delivery and postpartum depression. We further hypothesize that systematic inflammation is the causal mechanism in the association. Repeated measures of sleep duration during pregnancy will be obtained in a longitudinal cohort study design. Socio-demographic information and prior medical and obstetrical history will be collected through survey questionnaires and medical record abstraction. Repeated samples of pro-inflammatory cytokines levels from blood serum will also be ascertained. Findings from the proposed study are likely to have significant implications in facilitating the management and prevention of spontaneous preterm delivery and postpartum depression. My long-term research goal is to obtain training in sleep medicine research and combine it with my background in biostatistics and epidemiology to become a productive, independent maternal and fetal medicine researcher with a focus on sleep medicine. My mentors and I have developed a comprehensive and structured training plan that includes coursework, seminars and conferences, and mentored independent research projects. My prior training in Epidemiology, Biostatistics, maternal and child health place me in the right position to further my training in sleep medicine and to investigate the role sleep duration during pregnancy plays in adverse maternal and fetal outcomes. PUBLIC HEALTH RELEVANCE: Findings from the proposed study will enhance our understanding of sleep duration during pregnancy and its effects on spontaneous preterm delivery and postpartum depression. As it is widely documented that postpartum depression adversely affects maternal-child relationships and child development, the identification of sleep as a target of interventions in pregnancy would have substantial importance from a public health standpoint.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2014 ( Subtotal = $0 )
2014	2012	SAINT LOUIS UNIVERSITY	3500 LINDELL BLVD/FITZG'D HALL	SAINT LOUIS	MO	63103	SAINT LOUIS CITY	USA	Mental Health Research Career/Scientist Development Awards	000	3	1/6/2014	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2012 ( Subtotal = $157,424 )
2012	2012	SAINT LOUIS UNIVERSITY	3500 LINDELL BLVD/FITZG'D HALL	SAINT LOUIS	MO	63103	SAINT LOUIS CITY	USA	Mental Health Research Career/Scientist Development Awards	000	3	5/16/2012	NON-COMPETING CONTINUATION	$157,424
														Subtotal = $157,424

Issue Date FY: 2011 ( Subtotal = $156,720 )
2011	2011	SAINT LOUIS UNIVERSITY	3500 LINDELL BLVD/FITZG'D HALL	SAINT LOUIS	MO	63103	SAINT LOUIS CITY	USA	Mental Health Research Career/Scientist Development Awards	000	2	6/1/2011	NON-COMPETING CONTINUATION	$156,720
														Subtotal = $156,720

Issue Date FY: 2010 ( Subtotal = $152,544 )
2010	2010	SAINT LOUIS UNIVERSITY	3500 LINDELL BLVD/FITZG'D HALL	SAINT LOUIS	MO	63103	SAINT LOUIS CITY	USA	Mental Health Research Career/Scientist Development Awards	000	1	6/7/2010	NEW	$152,544
														Subtotal = $152,544

Grand Total All Awards = $466,688

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Sleep Duration During Pregnancy and the Risk of Postpartum Depression

Award Number: K01MH085976

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 06/07/2010

PERIOD OF PERFORMANCE END DATE: 05/31/2014

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