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HORMONES AND BEHAVIORAL DEVELOPMENT

Award Number: K01MH001992
ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/02/2000
PERIOD OF PERFORMANCE END DATE: 08/31/2005

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HORMONES AND BEHAVIORAL DEVELOPMENT - DESCRIPTION (Adapted from applicant's description): The general purpose of this proposal is to examine the behavioral and neurobiological consequences of development exposure to oxytocin (OT). Changes in OT are particularly likely to occur around the time of birth, and the proposed hypothesis is that the consequences of exposure to OT during the neonatal period may be long-lasting, producing functional changes in adulthood. This hypothesis will be examined in the context of female reproductive behaviors, which are particularly sensitive to the effects of OT and steroid hormones and their interactions. Developmental exposure to OT also may affect CNS levels of OT receptors, which could in turn alter sensitivity to OT in adulthood. In addition to behavioral assessments, the investigator proposes using neuroanatomical methods to index, as a function of neonatal manipulations of OT, both OT and OT receptors in adulthood. Developmental exposure to OT may affect adult behavior by influencing steroid sensitivity; this hypothesis will be examined by the measurement of estrogen or progesterone receptors. In addition, the effects of development exposure to OT on arginine vasopressin (AVP) and its receptor (V1a) will be examined; AVP is closely related to OT in both structure and function. Finally, a nonspecific marker of cellular activity (c-Fos) will be used to index the capacity of animals with different developmental histories to respond to adult treatment with estrogen or OT. The behavioral effects of both OT and estrogen can be species specific; for this reason two animal models (prairie voles and rats) have been selected, taking into account the advantages of each for examining the behavioral effects of both OT and steroid hormones and their interactions.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2004 ( Subtotal = $116,421 )
2004	2004	UNIVERSITY OF ILLINOIS AT CHICAGO	809 S MARSHFIELD AVE, 511 MB	CHICAGO	IL	60612	COOK	USA	Indicates awards funded from multiple programs	000	5	9/17/2004	NON-COMPETING CONTINUATION	$116,421
														Subtotal = $116,421

Issue Date FY: 2003 ( Subtotal = $113,659 )
2003	2003	UNIVERSITY OF ILLINOIS AT CHICAGO	809 S MARSHFIELD AVE, 511 MB	CHICAGO	IL	60612	COOK	USA	Indicates awards funded from multiple programs	000	4	8/26/2003	NON-COMPETING CONTINUATION	$113,659
														Subtotal = $113,659

Issue Date FY: 2002 ( Subtotal = $110,978 )
2002	2002	UNIVERSITY OF ILLINOIS AT CHICAGO	809 S MARSHFIELD AVE, 511 MB	CHICAGO	IL	60612	COOK	USA	Indicates awards funded from multiple programs	000	3	9/9/2002	NON-COMPETING CONTINUATION	$110,978
														Subtotal = $110,978

Issue Date FY: 2001 ( Subtotal = $108,367 )
2001	2001	UNIVERSITY OF ILLINOIS URBANA CAMPUS	809 SOUTH WRIGHT STREET	CHAMPAIGN	IL	61820	CHAMPAIGN	USA	Indicates awards funded from multiple programs	000	2	9/1/2001	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$108,367
														Subtotal = $108,367

Issue Date FY: 2000 ( Subtotal = $99,477 )
2000	2000	UNIVERSITY OF MARYLAND	4101 CHESAPEAKE BLDG	COLLEGE PARK	MD	20742	PRINCE GEORGES	USA	Indicates awards funded from multiple programs	000	1	9/2/2000	NEW	$99,477
														Subtotal = $99,477

Grand Total All Awards = $548,902

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HORMONES AND BEHAVIORAL DEVELOPMENT

Award Number: K01MH001992

ORGANIZATION: NATIONAL INSTITUTE OF MENTAL HEALTH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/02/2000

PERIOD OF PERFORMANCE END DATE: 08/31/2005

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