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It's interpersonal: Relationship quality, behavioral-social rhythms, and cardiovascular disease risk among middle-aged couples

Award Number: K01HL179264
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 06/25/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2031

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It's interpersonal: Relationship quality, behavioral-social rhythms, and cardiovascular disease risk among middle-aged couples - Project Summary/Abstract Cardiovascular disease (CVD) is the primary cause of death among individuals with type 2 diabetes (T2D), exacerbated by the adverse effects of high blood glucose on cardiovascular health. This K01 proposal investigates the complex interrelationships between sleep, circadian rhythms, and marital dynamics in managing CVD risk. The study employs a novel dyadic approach and will explore how behavioral-social rhythms and relationship quality within couples have an impact on CVD biomarkers, where 1) both partners are overweight or obese and 2) at least one partner has T2D at least one partner has T2D. These couples are at risk for and likely to show daily variability in blood glucose (BG) levels94. This study will recruit 100 middle-aged couples to advance understanding of the factors contributing to increased CVD risk. Over an intensive 20-day period, real- world, real-time data will be collected using ecological momentary assessments (EMA), actigraphy, and blinded continuous glucose monitoring (CGM). The study's primary objectives are to examine the interdependence of behavioral–social rhythms between partners and their associations with CVD risk biomarkers, investigate the links between relationship quality and behavioral–social rhythms, and determine how behavioral–social rhythms mediate the associations between relationship quality and CVD risk biomarkers. The project will explore how partners mutually influence each other’s health outcomes by utilizing the actor–partner interdependence model. This research aligns with NIH’s mission by offering novel insights into the circadian mechanisms that underlie health and disease, setting the stage for a subsequent R01 to explore long-term cardiovascular outcomes and create novel non-invasive dyadic interventions. The K01 career development award will support acquiring essential skills and knowledge, enhancing the candidate’s capability as an independent researcher at the nexus of health, sleep and circadian science, and family systems. Training will be provided in several key areas: (1) gaining conceptual and methodological expertise in obesity and T2D-related CVD risk with the supervision of Dr. Kanaley and Dr. Manrique-Acevedo; (2) developing skills in EMA data organization, management, conceptualization, and analysis with the supervision of Dr. Trull; (3) gaining expertise in the role of sleep and circadian rhythms in cardiovascular and metabolic diseases with the supervision of Dr. Buysse and Dr. Kanaley; and (4) strengthening methodologies for managing and analyzing high-dimensional, intensively monitored data with the supervision of Dr. Trull and Dr. Huang. Supported by a multidisciplinary mentoring team, this project is poised to significantly advance the candidate’s potential to lead innovative research on how behavioral–social rhythms within marital relationships affect chronic disease outcomes, thereby informing long-term interventions to mitigate CVD risks associated with diabetes. This K01 proposal is set to fill significant research gaps and equip an emerging scholar with the comprehensive skill set required to lead interdisciplinary research aimed at mitigating CVD risks, making a substantial contribution to public health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $169,415 )
2026	2026	UNIVERSITY OF MISSOURI SYSTEM	121 UNIVERSITY HALL	COLUMBIA	MO	65211	BOONE	USA	Cardiovascular Diseases Research	000	1	6/25/2026	NEW	$169,415
														Subtotal = $169,415

Grand Total All Awards = $169,415

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It's interpersonal: Relationship quality, behavioral-social rhythms, and cardiovascular disease risk among middle-aged couples

Award Number: K01HL179264

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 06/25/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2031

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