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Proof of Concept Trial of a Mindful Walking Intervention for Black Women with Hypertension

Award Number: K01HL174819
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/15/2024
PERIOD OF PERFORMANCE END DATE: 04/30/2027

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Proof of Concept Trial of a Mindful Walking Intervention for Black Women with Hypertension - ABSTRACT Hypertension disproportionately affects Black women and is a key risk factor for cardiovascular disease, a leading cause of death. As many as 39.9% of Black women have hypertension compared to Asian women (21.9%), Hispanic women (28%), and White women (25.6%). Among women with hypertension, Black women are 2.3 times more likely than white women to have uncontrolled blood pressure (BP). Physical activity can reduce hypertension risk and incidence, but rates are low among Black women. The vast majority of Black women (83.3%), are not meeting the national guidelines for physical activity. Stress is known as a key risk factor for hypertension as well as a major barrier to physical activity among Black women. To address hypertension and physical activity disparities among Black women, we propose a technology-delivered mindful walking intervention to reduce stress, increase PA, and ultimately reduce blood pressure in Black women with hypertension. We will leverage a virtual physical activity intervention that integrates both stress management and walking for Black women with hypertension. We will conduct focus groups with Black women with hypertension who are insufficiently active to gather insights about 1) their perspectives on a remotely delivered mindful walking intervention, including the modality, goals, walking pad treadmills, and content; and 2) perspectives on the use of actigraphy and physical activity logs to measure steps and physical activity. These findings will inform the development of the intervention. Using the ORBIT model for intervention design, we will then develop and test the intervention in a 1-arm proof of concept study. Findings will inform the development of the intervention in preparation for an efficacy trial. We will enroll 30 Black women into a 12-week Facebook-delivered mindful walking intervention. Feasibility outcomes will include recruitment, retention, engagement, and acceptability. Physical activity behavior (steps, minutes of walking and moderate to vigorous activity), systolic and diastolic blood pressure, and perceived stress will also be measured. Following this proof-of-concept test, we will conduct semi-structured interviews with participants to further refine the intervention. Building on Dr. Kalinowski’s prior pilot work on mindfulness and hypertension in Black women, this study will provide her with training in designing, developing, and implementing technology-delivered physical activity interventions to reduce CVD risk among Black women. This project contributes to Dr. Kalinowski’s long-term goal of designing technology-delivered physical activity interventions that can be leveraged to reduce CVD burden among Black women. Dr. Kalinowski has access to a rich research environment at the University of Connecticut along with expert mentors who are dedicated to her training and long-term development as an independent researcher.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $75,572 )
2026	2026	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Cardiovascular Diseases Research	000	2	6/25/2026	SUPPLEMENT FOR EXPANSION	$75,572
														Subtotal = $75,572

Issue Date FY: 2025 ( Subtotal = $161,090 )
2025	2025	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Cardiovascular Diseases Research	000	2	8/29/2025	NON-COMPETING CONTINUATION	$161,090
														Subtotal = $161,090

Issue Date FY: 2024 ( Subtotal = $162,000 )
2024	2024	UNIVERSITY OF CONNECTICUT	438 WHITNEY RD EXTENSION UNIT 1133	STORRS	CT	06269	CAPITOL	USA	Cardiovascular Diseases Research	000	1	8/9/2024	NEW	$162,000
														Subtotal = $162,000

Grand Total All Awards = $398,662

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Proof of Concept Trial of a Mindful Walking Intervention for Black Women with Hypertension

Award Number: K01HL174819

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/15/2024

PERIOD OF PERFORMANCE END DATE: 04/30/2027

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