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Novel Methods for Evaluating the Association of Electronic Cigarette Use with Cardiovascular Health

Award Number: K01HL154130
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/01/2020
PERIOD OF PERFORMANCE END DATE: 06/30/2025

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Novel Methods for Evaluating the Association of Electronic Cigarette Use with Cardiovascular Health - Project Summary This proposed 5-year study brings together Dr. Stokes’ training in population health and research on tobacco use behaviors with additional training in tobacco regulatory science, cardiovascular (CV) epidemiology, advanced biostatistics, and applied data science. To this end, Dr. Stokes has assembled a multidisciplinary team of mentors and advisors to aid his training and studies. The K01 will support a complementary set of training activities, including formal coursework, participation in the Early Career Faculty Development Program, the NIH-funded Clinical and Translational Science Institute sponsored K-to-R PRIME program, and strong mentorship from experts in relevant fields, to help him in his professional development and transition to independence. Population-based evidence on the CV effects of e-cigarette use is sparse, and the particular components of e-cigarette aerosols that may be responsible for CV harm remain poorly elucidated. The proposed research will integrate state-of-the-art causal inference methods, mediation analyses, and unsupervised data clustering approaches with the study of CV effects of e-cigarette use. The applicant will 1) examine the association of e-cigarette use and product transitions with incident CV events; 2) estimate associations of e-cigarette use with risk factors and preclinical biomarkers of CV injury, and analyze biomarkers of exposure as potential mediators; and 3) identify unique biomarker signatures of e-cigarette exposure using a data-driven clustering approach, and associate clusters with preclinical biomarkers of CV injury. With high quality population data and novel statistical methods to optimally control for cigarette smoking and other tobacco product use, the results of this project will provide timely and rigorous evidence on the CV effects of e-cigarette use. Together with evaluating the mediating role of exposure biomarkers and clustered e- cigarette use behavior patterns, the results will inform Food and Drug Administration regulatory standards for product safety and guide primary and secondary public health interventions that aim to reduce tobacco-related CV harm. The methods and findings will also inform future studies focused on other non-cigarette tobacco products, such as little cigars, cigarillos, and smokeless tobacco products. The additional training and protected time afforded by the K01 will aid Dr. Stokes in making his transition to an independent investigator capable of securing R-series NIH funding.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	TRUSTEES OF BOSTON UNIVERSITY	85 EAST NEWTON ST # M-921	BOSTON	MA	02118	SUFFOLK	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	5	1/25/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $181,375 )
2024	2024	TRUSTEES OF BOSTON UNIVERSITY	85 EAST NEWTON ST # M-921	BOSTON	MA	02118	SUFFOLK	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	5	7/18/2024	NON-COMPETING CONTINUATION	$181,375
														Subtotal = $181,375

Issue Date FY: 2023 ( Subtotal = $179,794 )
2023	2023	TRUSTEES OF BOSTON UNIVERSITY	85 EAST NEWTON ST # M-921	BOSTON	MA	02118	SUFFOLK	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	4	7/10/2023	NON-COMPETING CONTINUATION	$179,794
														Subtotal = $179,794

Issue Date FY: 2022 ( Subtotal = $178,260 )
2022	2022	TRUSTEES OF BOSTON UNIVERSITY	85 E NEWTON ST M-921	BOSTON	MA	02118	SUFFOLK	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	3	8/23/2022	NON-COMPETING CONTINUATION	$178,260
														Subtotal = $178,260

Issue Date FY: 2021 ( Subtotal = $184,679 )
2021	2021	TRUSTEES OF BOSTON UNIVERSITY	85 E NEWTON ST M-921	BOSTON	MA	02118	SUFFOLK	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	2	8/5/2021	NON-COMPETING CONTINUATION	$184,679
														Subtotal = $184,679

Issue Date FY: 2020 ( Subtotal = $179,504 )
2020	2020	TRUSTEES OF BOSTON UNIVERSITY	85 E NEWTON ST M-921	BOSTON	MA	02118	SUFFOLK	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	1	8/1/2020	NEW	$179,504
														Subtotal = $179,504

Grand Total All Awards = $903,612

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Novel Methods for Evaluating the Association of Electronic Cigarette Use with Cardiovascular Health

Award Number: K01HL154130

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/01/2020

PERIOD OF PERFORMANCE END DATE: 06/30/2025

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