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Assessing the burden of dementia in transgender populations

Award Number: K01HL151902
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/15/2021
PERIOD OF PERFORMANCE END DATE: 03/21/2025

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Assessing the burden of dementia in transgender populations - Project Summary Building on research to assess risk factors for atherosclerotic cardiovascular disease (CVD) in transgender populations, the proposed project uses methods validated in the parent grant to characterize dementia, including Alzheimer’s Disease, in transgender populations. The project’s main aim will be to use a robust method of identifying transgender individuals within claims data to assess rates of dementia diagnoses among transgender persons compared to cisgender referents. Completing the proposed aims will 1) demonstrate the utility of prior work by utilizing methods validated in the parent grant; 2) reveal further evidence in a unique population of traditional risk factors for cardiovascular disease that are linked dementia; and 3) inform future research into aging and dementia prevention in transgender populations. By engaging in mentored research with Drs. Emelia Benjamin (Mentor), Michael Paasche-Orlow (Mentor), Howard Cabral (Mentor), and Sari Reisner (Mentor), and collaborators, and participating in seminars, conferences, and regular mentoring meetings, I will develop expertise in four new areas critical to my development as an independent clinician- scientist evaluating health outcomes to characterize and mitigate CVD and dementia risks for transgender individuals: 1) Quantitative methods to analyze claims-based & electronic health record data; 2) Quantitative methods to assess prediction models; 3) Clinical skills in transgender endocrinology, cardiology, & preventive care. Moreover, I will extend my grant writing and oral presentation skills by participating in grant writing courses and presenting at research meetings and seminars. Boston University offers junior scholars with the intellectual and practical resources they need to develop into successful independent investigators, including junior faculty seminars, grant writing, editing, and review services, and opportunities for intellectual exchange and collaboration with senior colleagues. An administrative supplement to my K01 award will provide me with the research experience, skills, and mentorship I need to build a cutting-edge independent research program that assesses and addresses cardiovascular health and its effects on additional outcomes such as dementia in sexual and gender minorities, particularly transgender adults.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL	BOSTON	MA	02118	SUFFOLK	USA	Cardiovascular Diseases Research	000	4	3/25/2025	NON-COMPETING CONTINUATION	$0
2025	2024	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL	BOSTON	MA	02118	SUFFOLK	USA	Cardiovascular Diseases Research	001	4	3/25/2025	SUPPLEMENT FOR EXPANSION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $197,968 )
2024	2024	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL	BOSTON	MA	02118	SUFFOLK	USA	Cardiovascular Diseases Research	001	4	6/11/2024	SUPPLEMENT FOR EXPANSION	$31,691
2024	2024	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL	BOSTON	MA	02118	SUFFOLK	USA	Cardiovascular Diseases Research	000	4	3/28/2024	NON-COMPETING CONTINUATION	$166,277
														Subtotal = $197,968

Issue Date FY: 2023 ( Subtotal = $166,320 )
2023	2023	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL STE 1	BOSTON	MA	02118	SUFFOLK	USA	Cardiovascular Diseases Research	000	3	4/4/2023	NON-COMPETING CONTINUATION	$166,320
														Subtotal = $166,320

Issue Date FY: 2022 ( Subtotal = $166,320 )
2022	2022	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL STE 1	BOSTON	MA	02118	SUFFOLK	USA	Cardiovascular Diseases Research	000	2	3/24/2022	NON-COMPETING CONTINUATION	$166,320
														Subtotal = $166,320

Issue Date FY: 2021 ( Subtotal = $166,320 )
2021	2021	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CENTER PL STE 1	BOSTON	MA	02118	SUFFOLK	USA	Cardiovascular Diseases Research	000	1	4/14/2021	NEW	$166,320
														Subtotal = $166,320

Grand Total All Awards = $696,928

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Assessing the burden of dementia in transgender populations

Award Number: K01HL151902

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/15/2021

PERIOD OF PERFORMANCE END DATE: 03/21/2025

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