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Cardiovascular Disparities among Bereaved Latinos and Non-Latino Whites and Factors that Facilitate Resilience: A Biobehavioral Approach

Award Number: K01HL150247
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/16/2022
PERIOD OF PERFORMANCE END DATE: 12/31/2024

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Cardiovascular Disparities among Bereaved Latinos and Non-Latino Whites and Factors that Facilitate Resilience: A Biobehavioral Approach - ABSTRACT The proposed five-year plan for Dr. Luz Garcini's K01 Mentor Career Development Award will help launch her independent research career in biobehavioral health disparities and cardiovascular disease (CVD) risk. In the proposed project, Dr. Garcini aims at filling a gap in the literature by understanding how bereavement increases CVD risk, including detecting relevant ethnic disparities and identifying protective factors during this difficult life transition. The proposed training and mentoring plan will supplement Dr. Garcini's expertise in health disparities and community-based research with a foundation in CVD and psychoneuroimmunology (PNI) at premiere academic and medical institutions under the mentorship of renowned experts. The proposed research will use data from a longitudinal study among 96 recently (<2 months) bereaved adults (50% Latino, 50% Non-Latino White) with CVD risk assessments (i.e., glucocorticoid (GC) resistance and inflammation) done at baseline, 3, 6, and 12 months post enrollment. Survey measures of relevant mediators and moderators will take place at each time point, with a qualitative interview done after the last visit. The proposed project will draw on Dr. Garcini's expertise, along with a mentoring team at the forefront of biomedical science, to conduct the following aims using an interdisciplinary and culturally sensitive approach. AIM 1. To assess ethnic differences (Latinos, non-Latino Whites) in the association between grief symptoms and CVD risk (GC resistance and inflammation) among bereaved adults cross-sectionally and longitudinally. Hypothesis 1. The strength of the association between grief symptoms and CVD risk will be relatively stronger among Latinos compared to Non-Latino Whites. AIM 2. To identify contextual and cultural factors that facilitate coping with bereavement among Latinos and non-Latino Whites. AIM 3. To supplement Dr. Garcini's expertise in community-based research and health disparities with a foundation in CVD and psychoneuroimmunology (PNI) at premiere institutions and under the mentorship of renowned experts with the goal of increasing faculty diversity in the biomedical sciences. The proposed studies will offer an invaluable context to apply these concepts in a meaningful way—integrating didactics and experience, with the mentorship of an advising team of experts. The proposed research will provide novel information about mechanisms and predictors that underlie CVD risk in a vulnerable population about which little is known, while also identifying protective factors that foster resilience. The longitudinal design will provide valuable information to identify critical time points for intervention. The interdisciplinary training plan will equip Dr. Garcini with extensive knowledge of CVD and PNI skills to devote her career to the study of biobehavioral health disparities, CVD risk, and social determinants of health, which is needed to inform the development of interventions aimed at reducing disease burden.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$152,429 )
2025	2024	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Cardiovascular Diseases Research	001	5	4/30/2025	NON-COMPETING CONTINUATION	-$148,068
2025	2023	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Cardiovascular Diseases Research	000	4	4/30/2025	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	-$4,361
														Subtotal = -$152,429

Issue Date FY: 2024 ( Subtotal = $148,068 )
2024	2024	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Cardiovascular Diseases Research	000	5	1/19/2024	NON-COMPETING CONTINUATION	$148,068
2024	2023	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Cardiovascular Diseases Research	002	4	7/25/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$142,799
2024	2022	THE UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cardiovascular Diseases Research	001	3	7/25/2024	NON-COMPETING CONTINUATION	-$142,799
														Subtotal = $148,068

Issue Date FY: 2023 ( Subtotal = $148,068 )
2023	2023	WILLIAM MARSH RICE UNIVERSITY	6100 MAIN ST	HOUSTON	TX	77005	HARRIS	USA	Cardiovascular Diseases Research	001	4	12/14/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$148,068
2023	2022	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cardiovascular Diseases Research	000	3	12/14/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $148,068

Issue Date FY: 2022 ( Subtotal = $148,068 )
2022	2022	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cardiovascular Diseases Research	000	3	3/15/2022	NON-COMPETING CONTINUATION	$148,068
														Subtotal = $148,068

Issue Date FY: 2021 ( Subtotal = $148,068 )
2021	2021	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cardiovascular Diseases Research	000	2	3/24/2021	NON-COMPETING CONTINUATION	$148,068
														Subtotal = $148,068

Issue Date FY: 2020 ( Subtotal = $148,068 )
2020	2020	UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER OF SAN ANTONIO	7703 FLOYD CURL DR	SAN ANTONIO	TX	78229	BEXAR	USA	Cardiovascular Diseases Research	000	1	3/6/2020	NEW	$148,068
														Subtotal = $148,068

Grand Total All Awards = $587,911

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Cardiovascular Disparities among Bereaved Latinos and Non-Latino Whites and Factors that Facilitate Resilience: A Biobehavioral Approach

Award Number: K01HL150247

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/16/2022

PERIOD OF PERFORMANCE END DATE: 12/31/2024

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