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Particulate Matter (PM) Metals and Racial Disparity in Cardiovascular (CVD) Risk Factors

Award Number: K01HL146944
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 02/17/2020
PERIOD OF PERFORMANCE END DATE: 01/31/2026

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Particulate Matter (PM) Metals and Racial Disparity in Cardiovascular (CVD) Risk Factors - Summary/Abstract Given the complex composition of pollutants such as particulate matter PM in the environment, it is believed that our exposure is not limited to one chemical at a time but to several possible mixtures with varying composition and mix ratios. These mixtures could be formed because they are emitted at the same time from the same source origin as latent factors. As a result, humans are more susceptible to exposure to these mixtures as characterized by these latent factors. Factor analysis is one tool used in the literature to define mixtures. Unfortunately statistical methods of identifying mixtures are limited. Additionally, exposure to PM chemicals during pregnancy is known to be harmful to both mother and child. To address the problem a new method of identifying mixtures exposure based on extension of the traditional factor analysis combined with source apportionment methods will be used. This proposal will test the following hypothesis: Hypothesis 1: Exposure to PM mixture metals during pregnancy increased the risk of cardiovascular disease (CVD) risk factors among black and Hispanic minorities and vary by trimester. Hypothesis 2: CVD risk factors are mediators between PM metals exposure and child development, through the following Aims. 1) Quantify mixtures and estimate mother's exposure during various trimesters of pregnancy. We will use the newly developed Bayesian extended factor analysis (FA), based on the flexibility of Bayesian statistics and the decomposition of the error covariance matrix combined with SAM models to estimate metal mixtures. We will perform a spatio-temporal analysis of the mixtures using Generalized Additive Mixed Models(GAMM). We will use the inverse distance weighting method to estimate mother's inhaled quantities during each trimester of pregnancy. 2) Investigate CVD risk factors difference among black and white and interaction between air pollution and race/ethnicity by trimester. We will use logistic regression analysis and generalized spatial linear model for this aim. 3) Investigate CVD risk factors moderating between mixture metals exposure and infant mortality. We will use structural equation modeling (SEM) to investigate wich risk factors is in the pathway between exposure and child mortality. Results from the proposed studies could have implications in identifying mixtures exposures, their chemical toxicity and relative implication in CVD during pregnancy.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $175,643 )
2024	2024	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Cardiovascular Diseases Research	000	5	2/1/2024	NON-COMPETING CONTINUATION	$175,643
														Subtotal = $175,643

Issue Date FY: 2023 ( Subtotal = $175,643 )
2023	2023	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Cardiovascular Diseases Research	000	4	1/20/2023	NON-COMPETING CONTINUATION	$175,643
														Subtotal = $175,643

Issue Date FY: 2022 ( Subtotal = $175,207 )
2022	2022	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Cardiovascular Diseases Research	000	3	1/10/2022	NON-COMPETING CONTINUATION	$175,207
														Subtotal = $175,207

Issue Date FY: 2021 ( Subtotal = $174,667 )
2021	2021	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Cardiovascular Diseases Research	000	2	1/15/2021	NON-COMPETING CONTINUATION	$174,667
														Subtotal = $174,667

Issue Date FY: 2020 ( Subtotal = $176,586 )
2020	2020	FLORIDA INTERNATIONAL UNIVERSITY	11200 SW 8TH ST	MIAMI	FL	33199	MIAMI-DADE	USA	Cardiovascular Diseases Research	000	1	2/17/2020	NEW	$176,586
														Subtotal = $176,586

Grand Total All Awards = $877,746

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Particulate Matter (PM) Metals and Racial Disparity in Cardiovascular (CVD) Risk Factors

Award Number: K01HL146944

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 02/17/2020

PERIOD OF PERFORMANCE END DATE: 01/31/2026

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