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Cognitive Motor Interference Assessment for Improving Neurologic and Physical Disability Outcomes in Survivors of Severe Acute Respiratory Failure (CAMINANDO) Phase II

Award Number: K01HL140279
ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

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Project Summary/Abstract Severe acute respiratory failure is the most common organ failure in the intensive care unit, the most severe form of which is acute respiratory failure syndrome. Understanding and preventing the long-term physical and cognitive impairments that is the legacy of surviving acute respiratory failure (ARF) is the career goal of this junior minority investigator with previous clinical training in Pulmonary, Critical Care and research training in Clinical Epidemiology. Although previous research in ARF has examined mobility outcomes independently from the cognitive outcomes, emerging evidence suggests that mobility and cognitive outcomes are intertwined. Cognitive Motor Interference (CMI) is an emerging risk assessment and treatment approach for improving disability outcomes in many patient populations. Dr. Hope describes a mentored research project and specific career development plan which will enable him to become an expert in CMI assessments in patients with acute respiratory failure. The research proposal aims to leverage the NHLBI funded Prevention and Early Treatment of Acute Lung Injury (PETAL) network to define the scope, pattern and predictive validity of assessing acute respiratory failure patients for CMI while in the hospital. The research proposal's second aim is to conduct a single-center randomized clinical trial of hospital based CMI-based training in acute respiratory failure patients. During the award period, Dr. Hope has developed a structured plan to build on his previous training by attaining skills in four additional areas: 1) measuring cognitive motor interference in acutely ill patients; 2) understanding and intervening on disability outcomes after critical illness; 3) the management of clinical trials and 4) structured equation modeling. As part of this career development award, Dr. Hope will be a co-Principal Investigator for PETAL network studies at his institution and will serve as site Principal Investigator for an NHLBI funded ancillary study called PRIMROSE. As a member of the PETAL Network Long-Term Outcomes Working Group Committee, he will be involved, along with his mentors and collaborators, with developing recommendations for measuring long-term outcomes in the PETAL network studies. Dr. Hope will work closely with co-mentors in Neurology, Geriatrics and Critical Care with expertise in cognitive and mobility outcomes; He will also work with advisors and collaborators in Rehabilitation Medicine with expertise in the disability process in acutely ill patients. Through a mix of formal and informal coursework, practical experience, local and international meetings along with directed feedback from this multi-disciplinary team of mentors and advisors, Dr. Hope will be prepared to become an independent investigator by the end of this award period.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $0 )
2024	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Lung Diseases Research	000	6	2/16/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $0 )
2023	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Lung Diseases Research	003	6	10/18/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2023	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Lung Diseases Research	002	6	10/17/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$223,656
2023	2021	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Lung Diseases Research	001	5	10/17/2022	NON-COMPETING CONTINUATION	-$176,580
2023	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Lung Diseases Research	000	4	10/17/2022	NON-COMPETING CONTINUATION	-$47,076
														Subtotal = $0

Issue Date FY: 2022 ( Subtotal = $176,580 )
2022	2022	OREGON HEALTH & SCIENCE UNIVERSITY	3181 SW SAM JACKSON PARK RD	PORTLAND	OR	97239	MULTNOMAH	USA	Lung Diseases Research	001	6	9/2/2022	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$176,580
2022	2021	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Lung Diseases Research	000	5	9/1/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $176,580

Issue Date FY: 2021 ( Subtotal = $176,580 )
2021	2021	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Lung Diseases Research	000	5	3/10/2021	NON-COMPETING CONTINUATION	$176,580
														Subtotal = $176,580

Issue Date FY: 2020 ( Subtotal = $176,580 )
2020	2020	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Lung Diseases Research	000	4	3/2/2020	NON-COMPETING CONTINUATION	$176,580
														Subtotal = $176,580

Issue Date FY: 2019 ( Subtotal = $177,120 )
2019	2019	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Lung Diseases Research	004	3	3/25/2019	NON-COMPETING CONTINUATION	$177,120
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Lung Diseases Research	001	2	2/28/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$21,852
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Lung Diseases Research	003	2	3/7/2019	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$25,248
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Lung Diseases Research	000	1	2/27/2019	NEW	-$21,852
2019	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Lung Diseases Research	002	1	3/7/2019	NEW	-$25,248
														Subtotal = $177,120

Issue Date FY: 2018 ( Subtotal = $177,660 )
2018	2018	ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.	1300 MORRIS PARK AVE	BRONX	NY	10461	BRONX	USA	Lung Diseases Research	000	1	2/28/2018	NEW	$177,660
														Subtotal = $177,660

Grand Total All Awards = $884,520

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Cognitive Motor Interference Assessment for Improving Neurologic and Physical Disability Outcomes in Survivors of Severe Acute Respiratory Failure (CAMINANDO) Phase II

Award Number: K01HL140279

ORGANIZATION: NATIONAL HEART, LUNG, & BLOOD INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

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