PROJECT SUMMARY
The purpose of this Mentored Career Development Award to Promote Faculty Diversity in Biomedical Research (K01) is
to support Dr. White's development into an independent biomedical researcher and leader in pulmonary disease, genetic
epidemiology, pharmacogenetics, and health disparities research with a focus on obese-asthma in minority children.
Obese-asthma is a severe asthma phenotype highly prevalent in children; specifically, Latino and African American
children carry the majority of the disease burden. Dr. White's long-term career goal is to create a research program
centered on the identification of genetic and genomic risk factors associated with risk of obese-asthma and obese-asthma
related phenotypes (i.e. exacerbations, drug response) in minority children. The proposed mentored research for this
application is to apply an integrative genomics approach to identify common and rare genetic variants, and gene
expression patterns, associated with obese-asthma in African American, Puerto Rican, and Mexican American children.
To support this research and Dr. White's goal of becoming an independent researcher, this K01 proposal includes formal
mentored training through didactic coursework, hands-on internships and tailored tutorials in genomic analysis and health
disparities research, immersive workshops in advanced next generation sequencing analysis, R01 grant writing, and
responsible conduct in research. This training will be applied to the completion of the proposed research via three specific
aims: (1) identify common and rare variants associated with obese-asthma risk using whole genome sequencing data, (2)
identify genes that are differential expressed in children with obese-asthma versus those without obese-asthma, (3) use a
heuristic approach to prioritize variants associated with obese-asthma in the discovery population in five independent
replication populations. To achieve these goals, Dr. White has assembled a multi-disciplinary mentoring team comprised
of a primary mentor, Dr. Esteban Burchard, Director of the UCSF Center on Genes, Environment, and Health, and several
co-mentors including Drs. Max Seibold, Nadav Ahituv, Noah Zaitlen, Kirsten Bibbins-Domingo, and David Erle. The
University of California, San Francisco is the ideal environment for the proposed training as it provides access to experts
in asthma, genetics, epidemiology, bioinformatics, and world-class biomedical facilities and equipment.
Dr. White is an African American statistical geneticist, with a history of productive collaboration with her mentoring team
as well as a documented commitment to mentoring young scientists from under-represented minority groups. Completion
of the proposed research and career development activities in this application will inform the development of an R01
proposal and enable Dr. White to develop an innovative research program in obese-asthma genetics and genomics. With
support from this award, Dr. White can become a leader in genetic epidemiology and continue to serve as a research
mentor and role model for young minority scientists.