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The influence of brain organization and postural behavior on progression of back pain symptoms in young adults.

Award Number: K01HD092612
ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/15/2018
PERIOD OF PERFORMANCE END DATE: 06/30/2023

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The influence of brain organization and postural behavior on progression of back pain symptoms in young adults. - Project Summary/Abstract Candidate. The candidate is an Assistant Professor in Crean College of Health and Behavioral Sciences, at Chapman University. Her research to date has demonstrated altered postural coordination in individuals with low back pain (LBP) and examined neural correlates of anticipatory postural adjustments in the trunk. Her long- term goal is to develop rehabilitation interventions to reduce the development of chronic LBP. This project will help her to understand the influence of neuromechanical and psychological factors on LBP, and will prepare her to design and conduct large longitudinal and clinical trials. Mentorship team and training plan. Primary mentor, Dr. Laura M. Glynn, has extensive experience of conducting prospective studies investigating biopsychosocial influences on brain and behavior. She provides expertise in longitudinal study design and multifactorial analysis, as well as guidance on career development. Dr. Steven C. Cramer is an expert on central nervous system recovery who will advise on magnetic resonance imaging of the sensorimotor system. Dr. Linda Van Dillen has substantial experience in clinical research of individuals with LBP. A mentored practicum at her lab will provide direct experience of management of R01-funded clinical trials. Dr. Jesse V. Jacobs has expertise in neural mechanisms underlying postural coordination. Dr. Rongwen Tain will advise on technical aspects of magnetic resonance imaging and Dr. Babak Shahbaba will provide statistical support. The candidate will also complete didactic training in neuroimaging, multivariate data analysis, and clinical research. Environment. The candidate has substantial opportunities for collaboration and academic development at Chapman, and use of a fully equipped motion capture laboratory. She has access to additional intellectual development opportunities and MRI scanning facilities at University of California, Irvine. Research. The highest incidence of new episodes of LBP occurs during young adulthood. The objective of this study is to identify neuromechanical risk factors for recurrence/progression of LBP in young adults. Aim 1 will use electromyography to determine if changes in trunk/pelvis postural coordination following fatiguing paraspinal exercise are greater in asymptomatic young adults with a history of LBP than those with no history of LBP. Aim 2 will establish if there are alterations in central sensorimotor morphology, connectivity, or activity in young adults with a history of LBP, whether the connectivity and activation differences between groups are more evident following fatiguing exercise, and whether this brain reorganization is associated with altered postural coordination. Aim 3 will identify if neuromechanical factors are independently associated with recurrence/progression of LBP symptoms over 18 months.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = -$5,626 )
2024	2022	CHAPMAN UNIVERSITY	1 UNIVERSITY DR	ORANGE	CA	92866	ORANGE	USA	Child Health and Human Development Extramural Research	000	5	1/22/2024	NON-COMPETING CONTINUATION	-$5,626
														Subtotal = -$5,626

Issue Date FY: 2022 ( Subtotal = $119,135 )
2022	2022	CHAPMAN UNIVERSITY	ONE UNIVERSITY DR	ORANGE	CA	92866	ORANGE	USA	Child Health and Human Development Extramural Research	000	5	6/27/2022	NON-COMPETING CONTINUATION	$119,135
														Subtotal = $119,135

Issue Date FY: 2021 ( Subtotal = $129,632 )
2021	2021	CHAPMAN UNIVERSITY	ONE UNIVERSITY DR	ORANGE	CA	92866	ORANGE	USA	Child Health and Human Development Extramural Research	000	4	7/28/2021	NON-COMPETING CONTINUATION	$129,632
														Subtotal = $129,632

Issue Date FY: 2020 ( Subtotal = $130,064 )
2020	2020	CHAPMAN UNIVERSITY	ONE UNIVERSITY DR	ORANGE	CA	92866	ORANGE	USA	Child Health and Human Development Extramural Research	000	3	7/10/2020	NON-COMPETING CONTINUATION	$130,064
														Subtotal = $130,064

Issue Date FY: 2019 ( Subtotal = $130,162 )
2019	2019	CHAPMAN UNIVERSITY	ONE UNIVERSITY DR	ORANGE	CA	92866	ORANGE	USA	Child Health and Human Development Extramural Research	000	2	6/10/2019	NON-COMPETING CONTINUATION	$130,162
														Subtotal = $130,162

Issue Date FY: 2018 ( Subtotal = $130,162 )
2018	2018	CHAPMAN UNIVERSITY	ONE UNIVERSITY DR	ORANGE	CA	92866	ORANGE	USA	Child Health and Human Development Extramural Research	000	1	7/10/2018	NEW	$130,162
														Subtotal = $130,162

Grand Total All Awards = $633,529

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The influence of brain organization and postural behavior on progression of back pain symptoms in young adults.

Award Number: K01HD092612

ORGANIZATION: NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/15/2018

PERIOD OF PERFORMANCE END DATE: 06/30/2023

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