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COMPUTER AIDED DIAGNOSIS AND FOLLOWUP OF ALZHEIMER'S DISEASE

Award Number: K01EB006878
ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/20/2007
PERIOD OF PERFORMANCE END DATE: 07/31/2011

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COMPUTER AIDED DIAGNOSIS AND FOLLOWUP OF ALZHEIMER'S DISEASE - DESCRIPTION (provided by applicant): The aging of the population over the next quarter century will increase the already substantial personal, social and governmental costs of Alzheimer's disease. The future of healthcare of AD lies in the early diagnosis and treatment of AD. Neuroimaging is playing an increasingly critical role in research and clinical practice as valid early markers could be developed for both disease detection and monitoring. This research will come up with novel computational tools for computer aided diagnosis and followup of Alzheimer's disease, which is a substantial contribution to an important problem of general public health. During the award period, the applicant's career development focuses on developing novel computational methods for computer aided diagnosis and follow-up of AD. The applicant's career training focuses on 1) obtaining in-depth knowledge and hands-on experience in medical imaging; 2) obtaining in- depth knowledge in clinical neuroanatomy; 3) obtaining in-depth understanding of clinical diagnosis and follow-up of AD; 4) obtaining in-depth knowledge of biostatistics; 5) obtaining moderate knowledge in neuropathology, neurobiology, neurology, neurogenetics of AD. In this 4-year K01 proposal, the applicant will develop novel neuroimage analysis algorithms for Computer Aided Diagnosis and Follow-up of Alzheimer's Diseases (CADFAD). Specifically, we will 1) Develop and validate novel high-dimensional volume registration method based on deformation invariant attribute vectors (DIAV); (2) Develop and validate novel cortical surface based quantitation methods, including cortical surface reconstruction, registration, cortical attributes mapping, statistical inference, and visualization; and (3) Develop and validate novel gray matter diffusivity quantitation methods.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2010 ( Subtotal = $119,030 )
2010	2010	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC	BUSINESS SERVICES BUILDING	ATHENS	GA	30602	CLARKE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	5	7/29/2010	NON-COMPETING CONTINUATION	$119,030
														Subtotal = $119,030

Issue Date FY: 2009 ( Subtotal = $120,010 )
2009	2009	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC	BUSINESS SERVICES BUILDING	ATHENS	GA	30602	CLARKE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	4	7/20/2009	NON-COMPETING CONTINUATION	$120,010
														Subtotal = $120,010

Issue Date FY: 2008 ( Subtotal = $112,445 )
2008	2008	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC	BUSINESS SERVICES BUILDING	ATHENS	GA	30602	CLARKE	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	3	9/23/2008	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$112,445
2008	2008	METHODIST HOSPITAL RESEARCH INSTITUTE	6565 FANNIN WP 802	HOUSTON	TX	77030	HARRIS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	2	7/10/2008	NON-COMPETING CONTINUATION	$0
														Subtotal = $112,445

Issue Date FY: 2007 ( Subtotal = $125,616 )
2007	2007	METHODIST HOSPITAL RESEARCH INSTITUTE	6565 FANNIN WP 802	HOUSTON	TX	77030	HARRIS	USA	Discovery and Applied Research for Technological Innovations to Improve Human Health	000	1	8/20/2007	NEW	$125,616
														Subtotal = $125,616

Grand Total All Awards = $477,101

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COMPUTER AIDED DIAGNOSIS AND FOLLOWUP OF ALZHEIMER'S DISEASE

Award Number: K01EB006878

ORGANIZATION: NATIONAL INSTITUTE Of BIOMEDICAL IMAGING & BIOENGINEERING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/20/2007

PERIOD OF PERFORMANCE END DATE: 07/31/2011

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