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Skeletal Muscle Mitochondrial Efficiency in GLP-1RA-induced Weight Loss

Award Number: K01DK147576
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/2026
PERIOD OF PERFORMANCE END DATE: 02/28/2031

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Skeletal Muscle Mitochondrial Efficiency in GLP-1RA-induced Weight Loss - PROJECT SUMMARY/ABSTRACT Obesity and its associated comorbidities, including insulin resistance and type 2 diabetes, are major public health challenges. Glucagon-like peptide-1 receptor agonists (GLP-1RAs), such as semaglutide, promote substantial weight loss and metabolic improvements, but the cellular mechanisms linking weight loss to improved skeletal muscle energetics remain unclear. Mitochondrial oxidative phosphorylation (OXPHOS) efficiency in skeletal muscle, defined as ATP produced per oxygen consumed, is a critical determinant of systemic energy balance. Preliminary data suggest that semaglutide enhances OXPHOS efficiency, but it is unknown whether this effect scales with weight loss, persists after treatment cessation, or requires intact mitochondrial pathways. This project investigates how pharmacologically induced weight loss alters skeletal muscle mitochondrial efficiency and whether such adaptations contribute to improved energy expenditure and metabolic health. It will assess the durability of OXPHOS remodeling following treatment withdrawal and explore whether enhanced mitochondrial efficiency supports increased physical activity and sustained glycemic control. The research integrates physiological, biochemical, and metabolic analyses to define how skeletal muscle energetics mediate the systemic effects of weight loss. Findings will inform future strategies aimed at sustaining the metabolic benefits of weight loss in individuals with obesity.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $143,550 )
2026	2026	UNIVERSITY OF UTAH	201 PRESIDENTS CIR	SALT LAKE CITY	UT	84112	SALT LAKE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	6/19/2026	NEW	$143,550
														Subtotal = $143,550

Grand Total All Awards = $143,550

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Skeletal Muscle Mitochondrial Efficiency in GLP-1RA-induced Weight Loss

Award Number: K01DK147576

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/2026

PERIOD OF PERFORMANCE END DATE: 02/28/2031

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