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Neurodevelopment of executive function, appetite regulation, and obesity in children and adolescents

Award Number: K01DK135847
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 04/15/2023
PERIOD OF PERFORMANCE END DATE: 01/31/2028

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Neurodevelopment of executive function, appetite regulation, and obesity in children and adolescents - Dr. Adise is an excellent and ideal candidate for an NIDDK Mentored Research Scientist Development Award. As one of the few trained nutritional neuroscientists, her expertise bridges eating behavior, childhood obesity, and developmental cognitive and computational neuroscience. She has a strong publication and funding record across these domains. The overall goal of this proposal is to examine the relationship between weight gain and neurocognitive development during adolescence. This work addresses a critical public health issue: childhood obesity, which rates remain alarmingly high, and without proper identification of the causes, prevalence will continue to rise. While multiple contributors to obesity have been identified, the brain plays a central role in food intake. Under optimal conditions, neural circuits governing eating behavior support homeostatic regulation; however, external cues such as the sight, smell or taste of food can override internal hunger and satiety cues, leading to hedonic (i.e., reward-based overeating). Individual differences in these decision-making processes, particularly executive function and cognition, have been associated with overeating and weight gain. Yet, it remains unclear whether altered brain function precedes or results from excess weight, especially given that weight gain and food itself can influence brain structure and function. Thus, the proposed research plan has three specific aims: 1) To characterize the temporal and directional cause vs. consequence relationship between neuroanatomical and functional associations of executive function and obesity development throughout adolescence; 2) To determine if factors linked to optimal child health and development affect developmental trajectories of obesity and EF. 3) To examine how early life nutrition is related to the development of these brain regions and functions. Dr. Adise has proposed an innovative study to address these aims that employs magnetic resonance imaging (MRI), novel statistical analyses (e.g., latent growth curve modeling, machine learning) and behavioral and biological markers of appetite regulation. The career development plan supports the research aims and Dr. Adise’s transition to independence with training in 1) neurocognitive development with respect to sex- and pubertal-specific influence on brain maturation; 2) health-related influences on obesity-brain relationships; 3) Infant nutrition, appetite regulation, and body composition; and 4) Novel tools longitudinal data analysis. This award will help to establish the foundation on which Dr. Adise will build her expertise as a leading scientist in the field of neurocognitive development of pediatric ingestive behavior by providing the protected time to achieve the necessary training, experience, and mentorship.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $21,227 )
2026	2026	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 E CAMPUS RD RM 409	ATHENS	GA	30602	CLARKE	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	4	6/12/2026	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$155,293
2026	2025	CHILDREN'S HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	6/4/2026	NON-COMPETING CONTINUATION	-$134,066
2026	2025	CHILDREN'S HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	4/24/2026	NON-COMPETING CONTINUATION	$0
														Subtotal = $21,227

Issue Date FY: 2025 ( Subtotal = $148,837 )
2025	2025	CHILDREN'S HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	2/18/2025	NON-COMPETING CONTINUATION	$148,837
														Subtotal = $148,837

Issue Date FY: 2024 ( Subtotal = $148,837 )
2024	2024	CHILDREN'S HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	1/30/2024	NON-COMPETING CONTINUATION	$148,837
														Subtotal = $148,837

Issue Date FY: 2023 ( Subtotal = $149,937 )
2023	2023	CHILDRENS HOSPITAL LOS ANGELES	4650 W SUNSET BLVD	LOS ANGELES	CA	90027	LOS ANGELES	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	4/7/2023	NEW	$149,937
														Subtotal = $149,937

Grand Total All Awards = $468,838

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Neurodevelopment of executive function, appetite regulation, and obesity in children and adolescents

Award Number: K01DK135847

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 04/15/2023

PERIOD OF PERFORMANCE END DATE: 01/31/2028

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