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Metabolism, appetite, and physical activity in adolescents

Award Number: K01DK119545
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/01/2019
PERIOD OF PERFORMANCE END DATE: 08/31/2025

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Metabolism, appetite, and physical activity in adolescents - PROJECT SUMMARY/ABSTRACT Childhood obesity is the most serious public health problem of the 21st century, given the prevalence, global reach, and widespread health, economic, and social consequences. While weight gain at the most basic level is due to a chronic energy surplus, there are a host of influences that act on the energy balance system that remain largely unknown. Thus, there is a critical need to identify previously unexamined factors that may influence the energy balance system in order to develop effective interventions for prevention and treatment. Our long-term goal is to quantify the dynamic relationships between various physiological and psychological components of the energy balance system. Our short-term goal is to examine linkages between physical activity, appetite control, and energy metabolism in adolescents. The status quo as it relates to appetite control is that body weight status and related peripheral signals are a key regulator of energy intake. In contrast to body weight playing a primary role in energy regulation, our working hypothesis is that high levels of regular moderate-to-vigorous physical activity (MVPA) result in a metabolic phenotype consisting of enhanced metabolic function and proper regulation of appetite, which prevents the development of obesity. We have reported that adults with low levels of MVPA have dysregulated appetite control, evidenced by higher levels of energy intake and elevated levels of dietary disinhibition. Additionally, primary mentor Thyfault has observed that rats with low fitness possess dysregulated control of appetite and reduced hepatic fat oxidation compared to rats with high fitness. Based on these findings in adults and rodents, in addition to supportive work by others, we hypothesize that low levels of MVPA create a metabolic phenotype, leading to dysregulated appetite control which predisposes individuals to weight gain. To test this hypothesis we will perform two studies focused on the links between physical activity and appetite. For Study 1, we will assess metabolic function and appetite control in male and female adolescents stratified by bodyweight (normal vs overweight/obese) and physical activity (sedentary vs. active) using a 2 x 2 cross-sectional study design (N=40). For Study 2, we will examine the influence of MVPA on the same outcomes by randomly assigning sedentary overweight/obese adolescents (N=44) to either a structured-exercise group or no treatment control for three months. The specific aims of the proposed studies are: 1) To examine the association between physical activity and appetite control in adolescents, with metabolic function serving as a mediator; and, 2) To test if increased physical activity through an exercise intervention influences metabolic function and appetite control. At the completion of the proposed studies, it is our expectation that we will have described the independent effects of physical activity and body weight on energy metabolism and appetite in adolescents. This study will have a significant positive impact on the understanding of energy balance in adolescents, and will inform public health interventions that specifically target mechanisms associated with weight gain in youth. 1


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = -$17,015 )
2025	2023	CHILDRENS MERCY HOSPITAL	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	5	4/10/2025	SUPPLEMENT FOR EXPANSION	$0
2025	2023	CHILDRENS MERCY HOSPITAL	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	5	6/4/2025	NON-COMPETING CONTINUATION	-$11,344
2025	2023	CHILDRENS MERCY HOSPITAL	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	4/10/2025	NON-COMPETING CONTINUATION	$0
2025	2023	CHILDRENS MERCY HOSPITAL	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	003	5	6/4/2025	SUPPLEMENT FOR EXPANSION	-$5,672
														Subtotal = -$17,015

Issue Date FY: 2023 ( Subtotal = $217,281 )
2023	2023	CHILDRENS MERCY HOSPITAL	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	002	5	8/24/2023	NON-COMPETING CONTINUATION	$0
2023	2023	CHILDRENS MERCY HOSPITAL	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	5/12/2023	NON-COMPETING CONTINUATION	$144,854
2023	2023	CHILDRENS MERCY HOSPITAL	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	5	8/23/2023	SUPPLEMENT FOR EXPANSION	$72,427
														Subtotal = $217,281

Issue Date FY: 2022 ( Subtotal = $144,854 )
2022	2022	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	7/7/2022	NON-COMPETING CONTINUATION	$144,854
														Subtotal = $144,854

Issue Date FY: 2021 ( Subtotal = $144,854 )
2021	2021	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	5/19/2021	NON-COMPETING CONTINUATION	$144,854
														Subtotal = $144,854

Issue Date FY: 2020 ( Subtotal = $144,854 )
2020	2020	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	6/1/2020	NON-COMPETING CONTINUATION	$144,854
														Subtotal = $144,854

Issue Date FY: 2019 ( Subtotal = $146,354 )
2019	2019	CHILDREN'S MERCY HOSPITAL, THE	2401 GILLHAM RD	KANSAS CITY	MO	64108	JACKSON	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	7/24/2019	NEW	$146,354
														Subtotal = $146,354

Grand Total All Awards = $781,182

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Metabolism, appetite, and physical activity in adolescents

Award Number: K01DK119545

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/01/2019

PERIOD OF PERFORMANCE END DATE: 08/31/2025

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