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Cancer Survivorship Research and Training in Radiation Cystitis

Award Number: K01DK114334
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/01/2018
PERIOD OF PERFORMANCE END DATE: 06/30/2023

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Cancer Survivorship Research and Training in Radiation Cystitis - Cancer survivors are at risk for developing radiation cystitis (RC) after radiation therapy. RC is a debilitating bladder and may be life-threatening. Current therapies are inadequate and can have severe life changing side-effects. The absence of reliable treatment and early diagnostic markers is in part due to limited comprehension of the histological and molecular changes associated with the progression of this condition. I hypothesize that radiation-induced damage to the bladder vasculature drives the chronic inflammation, fibrosis and hematuria associated with RC. This hypothesis will be addressed through three specific aims: 1. Determine the effect of radiation therapy on bladder vasculature function, 2. Assess and target the inflammation in an animal model of RC, and 3. Validate urinary candidate biomarkers for early detection of RC. The study design includes assessing functional changes of endothelial cells and determining changes in ICAM-1 expression and its role in immune cell recruitment in response to irradiation. Non-irradiated and cyclophosphamide treated cells will serve as negative and positive controls respectively. Using a mouse model of RC, a timeline of molecular and histological bladder changes in response to radiation will be determined. Non-irradiated bladders and cyclophosphamide-induced cystitis in mice will be used as negative and positive controls for these studies respectively. Finally urine samples from RC patients with a history of prostate or cervical cancer will be used to develop a biomarker for RC. Controls consist of age-matched male and female urine samples. As a cancer survivor and a scientist, my ultimate career goal is to improve the quality of life of cancer survivors through my research. I plan on achieving this goal by becoming an independent translation investigator, focusing my research on urological complications from cancer therapies, and implementing my research findings into the clinic. Through my past research track record, I have extensive experience in basic science techniques in vascular and cancer biology. The additional necessary skills to successfully complete this research and training proposal will be acquired through mentorship and coursework in translational research, radiation, and biostatistics. In addition, I will be receiving practical training in viral infections and pathology. I will be receiving continuous mentorship from Drs. Chancellor and Lamb. Drs. Kanai and Wilson will serve as co-mentors. My mentors have a history of successful mentorship of NIH scientists and we have a superb and supportive training environment here at Beaumont Research Institute and Oakland University William Beaumont School of Medicine. The outcome of our studies can significantly improve the quality of life of many cancer survivors that are suffering with severe bladder complications due to radiation therapy. These studies could lead to finding effective therapy for RC as well as a urine biomarker for early detection of RC. This research study has great potential to improve the quality of life of cancer survivors suffering from this debilitating condition.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = -$39,393 )
2022	2020	WILLIAM BEAUMONT HOSPITAL	3601 W 13 MILE RD	ROYAL OAK	MI	48073	OAKLAND	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	11/28/2021	SUPPLEMENT FOR EXPANSION	-$39,393
														Subtotal = -$39,393

Issue Date FY: 2021 ( Subtotal = $0 )
2021	2020	WILLIAM BEAUMONT HOSPITAL	3601 W. THIRTEEN MILE RD	ROYAL OAK	MI	48073	OAKLAND	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	5/14/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2020 ( Subtotal = $183,464 )
2020	2020	WILLIAM BEAUMONT HOSPITAL	3601 W. THIRTEEN MILE RD	ROYAL OAK	MI	48073	OAKLAND	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	3	8/5/2020	SUPPLEMENT FOR EXPANSION	$54,000
2020	2020	WILLIAM BEAUMONT HOSPITAL	3601 W. THIRTEEN MILE RD	ROYAL OAK	MI	48073	OAKLAND	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	6/29/2020	NON-COMPETING CONTINUATION	$129,464
														Subtotal = $183,464

Issue Date FY: 2019 ( Subtotal = $129,464 )
2019	2019	WILLIAM BEAUMONT HOSPITAL	3601 W. THIRTEEN MILE RD	ROYAL OAK	MI	48073	OAKLAND	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	7/1/2019	NON-COMPETING CONTINUATION	$129,464
														Subtotal = $129,464

Issue Date FY: 2018 ( Subtotal = $130,955 )
2018	2018	WILLIAM BEAUMONT HOSPITAL	3601 W. THIRTEEN MILE RD	ROYAL OAK	MI	48073	OAKLAND	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	8/22/2018	NEW	$130,955
														Subtotal = $130,955

Grand Total All Awards = $404,490

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Cancer Survivorship Research and Training in Radiation Cystitis

Award Number: K01DK114334

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/01/2018

PERIOD OF PERFORMANCE END DATE: 06/30/2023

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