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Physical Activity in Pregnancy for Intergenerational Obesity Prevention

Award Number: K01DK105106
ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/21/2015
PERIOD OF PERFORMANCE END DATE: 06/30/2022

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Physical Activity in Pregnancy for Intergenerational Obesity Prevention - PROJECT ABSTRACT To curb the continuing obesity epidemic, ‘upstream’ prevention efforts are desperately needed. To inform such prevention efforts, increased scientific knowledge of the mechanisms through which physical activity (PA) in pregnancy, a modifiable lifestyle factor, may impact body size and composition in infancy is required. This K01 will provide Dr. Samantha F. Ehrlich Ph.D., with the expertise needed to achieve her career goals of reducing obesity and diabetes in women and children by promoting and ultimately increasing participation in PA. The central hypothesis of this proposal is that increasing PA during pregnancy may mitigate the development of obesity in both the mother (i.e., through appropriate GWG) and child (i.e., through appropriate birthweight and reduced body fat at birth, and developmental programming for appropriate weight/fat mass gains in infancy). The specific aims are as follows. Aim 1: To estimate the effects of PA during pregnancy on infant growth from birth to 1 year of age using novel methods that permit causal inference to be drawn from observational data. Aim 2: To estimate the effects of PA regime during pregnancy (i.e., objectively measured PA in early and late pregnancy) on infant body composition (i.e., percent body fat) from birth to 1 year of age using novel methods that permit causal inference to be drawn from observational data with time-dependent confounding (i.e., measures of PA, diet, and fat mass in early and late pregnancy). Aim 3: To conduct a pilot feasibility randomized controlled trial among women with GDM comparing the effects of a behavioral PA intervention (i.e., walking/stepping in place) versus general wellness education on PA levels, maternal glycemic profile in the third trimester, and infant size and anthropometrics. This research will expand scientific knowledge of the potential role of PA during pregnancy in ‘upstream’ obesity prevention. Dr. Assiamira Ferrara MD, Ph.D., Senior Research Scientist and Chief of the Women’s and Children’s Health Section at the KPNC Division of Research, will be my Primary Mentor (obesity prevention). Co-mentors with complementary expertise include Drs. David Bassett, Jr. (objectively measured PA), Hollie A. Raynor (nutrition and behavioral aspects of obesity prevention), and Romain Neugebauer (causal inference-based methods of analysis); Dr. Kelley Pettee Gabriel (PA epidemiology) is a Consultant. The research, new training and professional developmental afforded by this award will ensure Dr. Ehrlich’s successful transition to research independence in the area of PA during pregnancy for intergenerational obesity and diabetes prevention.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2023 ( Subtotal = -$274 )
2023	2021	UNIVERSITY OF TENNESSEE	201 ANDY HOLT TOWER	KNOXVILLE	TN	37996	KNOX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	12/6/2022	SUPPLEMENT FOR EXPANSION	-$274
														Subtotal = -$274

Issue Date FY: 2022 ( Subtotal = $0 )
2022	2021	UNIVERSITY OF TENNESSEE	1331 CIR PARK DR	KNOXVILLE	TN	37916	KNOX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	001	5	12/23/2021	SUPPLEMENT FOR EXPANSION	$0
2022	2020	UNIVERSITY OF TENNESSEE	1331 CIR PARK DR	KNOXVILLE	TN	37916	KNOX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	12/23/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2021 ( Subtotal = $48,245 )
2021	2021	UNIVERSITY OF TENNESSEE	1331 CIR PARK DR	KNOXVILLE	TN	37916	KNOX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	7/21/2021	SUPPLEMENT FOR EXPANSION	$48,245
														Subtotal = $48,245

Issue Date FY: 2020 ( Subtotal = $146,112 )
2020	2020	UNIVERSITY OF TENNESSEE	1331 CIR PARK DR	KNOXVILLE	TN	37916	KNOX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	5	1/8/2020	NON-COMPETING CONTINUATION	$146,112
														Subtotal = $146,112

Issue Date FY: 2019 ( Subtotal = $146,281 )
2019	2019	UNIVERSITY OF TENNESSEE	1331 CIR PARK DR	KNOXVILLE	TN	37916	KNOX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	4	12/20/2018	NON-COMPETING CONTINUATION	$146,281
														Subtotal = $146,281

Issue Date FY: 2018 ( Subtotal = $146,086 )
2018	2018	UNIVERSITY OF TENNESSEE	1331 CIR PARK DR	KNOXVILLE	TN	37916	KNOX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	3	12/4/2017	NON-COMPETING CONTINUATION	$146,086
														Subtotal = $146,086

Issue Date FY: 2017 ( Subtotal = $146,656 )
2017	2017	UNIVERSITY OF TENNESSEE	1331 CIR PARK DR	KNOXVILLE	TN	37916	KNOX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	2	12/14/2016	NON-COMPETING CONTINUATION	$146,656
														Subtotal = $146,656

Issue Date FY: 2016 ( Subtotal = $0 )
2016	2015	UNIVERSITY OF TENNESSEE	WEST CUMBERLAND AVENUE, SW	KNOXVILLE	TN	37916	KNOX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	12/4/2015	NEW	$0
														Subtotal = $0

Issue Date FY: 2015 ( Subtotal = $148,159 )
2015	2015	UNIVERSITY OF TENNESSEE	WEST CUMBERLAND AVENUE, SW	KNOXVILLE	TN	37916	KNOX	USA	Diabetes, Digestive, and Kidney Diseases Extramural Research	000	1	9/21/2015	NEW	$148,159
														Subtotal = $148,159

Grand Total All Awards = $781,265

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Physical Activity in Pregnancy for Intergenerational Obesity Prevention

Award Number: K01DK105106

ORGANIZATION: NATIONAL INSTITUTE OF DIABETES & DIGESTIVE & KIDNEY DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/21/2015

PERIOD OF PERFORMANCE END DATE: 06/30/2022

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