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Rehabilitation of Reading Deficits in Subacute Stroke using fMRI Neurofeedback and Motor Imagery

Award Number: K01DC019178
ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/2021
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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Rehabilitation of Reading Deficits in Subacute Stroke using fMRI Neurofeedback and Motor Imagery - Stroke is the leading cause of long-term disability in the US and worldwide. Unilateral stroke of the left- hemisphere causes reading and language deficits in 21-58% of stroke survivors and these deficits persist chronically, despite participation in therapy. The majority of the available reading treatments show the clearest benefits on trained materials. Therefore, there is an urgent need for new treatment strategies that can generalize outside of the treatment context. Biologically-based interventions can meet this challenge by directly influencing beneficial post-stroke plasticity. For example, real-time functional Magnetic Resonance Imaging Neurofeedback (fMRI NFB) is an innovative approach allowing participants to regulate their own brain activity. It uses a combination of mental strategies and concurrent brain activity feedback. Studies have shown that repeated efforts to self-regulate brain activity lead to learning-induced neural changes. Preliminary evidence also suggests that real-time fMRI NFB can improve post-stroke motor and cognitive function. The main goal of the present proposal is to build on this success and to advance biologically-inspired interventions for reading. Strong preliminary data show that reduced recruitment of the intact left-hemisphere reading areas is associated with suboptimal reading outcomes after stroke. In addition, pilot data suggest that right hand finger tap imagery can effectively activate the left inferior parietal region thought to support binding of visual orthographic information with sound representations during reading. Given that difficulty with orthography- phonology conversion is the most common deficit among left-hemisphere stroke survivors, the current project proposes to use right hand finger tap imagery in combination with fMRI NFB to help re-instate left inferior parietal activity during reading. It is hypothesized that efforts to increase reading-related brain activation in the left-hemisphere will re-engage the impaired reading mechanisms and may alleviate reading deficits. Under this K01 award, the applicant will develop skills necessary to test this hypothesis, namely in carrying out clinical trials using fMRI NFB and motor imagery. This project has 3 specific aims. Under Aim 1, the applicant will become proficient in specific hardware, software, pre- and post-processing requirements of fMRI NFB, gain NFB research experience, and acquire critical skills in motor imagery and clinical trial design. In Aim 2, the applicant will apply this training to conduct a clinical trial feasibility study for a combined fMRI NFB and motor imagery rehabilitation of reading impairments in left-hemisphere stroke. Lastly, under Aim 3, the applicant will characterize the neural mechanisms of reading in subacute stroke. At the end of this award period, the applicant will develop a valid and reliable paradigm for a neuroscience-based reading intervention that has the potential to change how reading deficits are treated. The methods developed here could be extended to other domains and to other clinical populations to improve cognitive rehabilitation outcomes.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $126,571 )
2025	2025	KESSLER FOUNDATION, INC	120 EAGLE ROCK AVE STE 100	EAST HANOVER	NJ	07936	MORRIS	USA	Research Related to Deafness and Communication Disorders	000	5	6/25/2025	NON-COMPETING CONTINUATION	$126,571
														Subtotal = $126,571

Issue Date FY: 2024 ( Subtotal = $129,301 )
2024	2024	KESSLER FOUNDATION, INC	120 EAGLE ROCK AVE STE 100	EAST HANOVER	NJ	07936	MORRIS	USA	Research Related to Deafness and Communication Disorders	000	4	6/21/2024	NON-COMPETING CONTINUATION	$129,301
														Subtotal = $129,301

Issue Date FY: 2023 ( Subtotal = $132,029 )
2023	2023	KESSLER FOUNDATION, INC.	120 EAGLE ROCK AVE STE 100	EAST HANOVER	NJ	07936	MORRIS	USA	Research Related to Deafness and Communication Disorders	001	3	6/28/2023	NON-COMPETING CONTINUATION	$132,029
2023	2022	KESSLER FOUNDATION, INC.	120 EAGLE ROCK AVE STE 100	EAST HANOVER	NJ	07936	MORRIS	USA	Research Related to Deafness and Communication Disorders	000	2	11/2/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $132,029

Issue Date FY: 2022 ( Subtotal = $134,759 )
2022	2022	KESSLER FOUNDATION, INC.	120 EAGLE ROCK AVE STE 100	EAST HANOVER	NJ	07936	MORRIS	USA	Research Related to Deafness and Communication Disorders	000	2	8/15/2022	NON-COMPETING CONTINUATION	$134,759
2022	2022	KESSLER FOUNDATION, INC.	120 EAGLE ROCK AVE STE 100	EAST HANOVER	NJ	07936	MORRIS	USA	Research Related to Deafness and Communication Disorders	001	2	9/8/2022	NON-COMPETING CONTINUATION	$0
														Subtotal = $134,759

Issue Date FY: 2021 ( Subtotal = $134,759 )
2021	2021	KESSLER FOUNDATION, INC.	120 EAGLE ROCK AVE STE 100	EAST HANOVER	NJ	07936	MORRIS	USA	Research Related to Deafness and Communication Disorders	001	1	6/25/2021	NEW	-$134,759
2021	2021	KESSLER FOUNDATION, INC.	120 EAGLE ROCK AVE STE 100	EAST HANOVER	NJ	07936	MORRIS	USA	Research Related to Deafness and Communication Disorders	000	1	6/11/2021	NEW	$134,759
2021	2021	KESSLER FOUNDATION, INC.	120 EAGLE ROCK AVE STE 100	EAST HANOVER	NJ	07936	MORRIS	USA	Research Related to Deafness and Communication Disorders	002	1	6/30/2021	NEW	$134,759
														Subtotal = $134,759

Grand Total All Awards = $657,419

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Rehabilitation of Reading Deficits in Subacute Stroke using fMRI Neurofeedback and Motor Imagery

Award Number: K01DC019178

ORGANIZATION: NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/2021

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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