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Impact of Synthetic Coolants vs. Menthol in Cigarettes on Abuse Liability and Use Behaviors

Award Number: K01DA061444
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/01/2025
PERIOD OF PERFORMANCE END DATE: 07/31/2030

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Impact of Synthetic Coolants vs. Menthol in Cigarettes on Abuse Liability and Use Behaviors - PROJECT ABSTRACT Menthol enhances the appeal of cigarettes and promotes nicotine dependence, leading the US FDA to propose a rule prohibiting menthol as a characterizing flavor in cigarettes. However, following restrictions on the sale of menthol cigarettes in California and Massachusetts, synthetic coolants have been added to cigarettes, potentially nullifying the public health benefit of the menthol restriction. This novel study aims to provide critical knowledge to understand the abuse liability and substitutability of synthetic coolants for menthol in cigarettes, employing both laboratory and naturalistic experiments. A total of 40 adults who smoke menthol cigarettes will complete a 3-phase, 3-week study. In phase 1, participants will smoke their usual brand menthol cigarette (UBMC) during a lab session and report daily usage for a week. Phase 2 will use a double-blinded, randomized crossover design, where each participant will complete three intensive lab sessions to smoke three, lab-prepared study products varying only in the absence or presence of menthol and synthetic coolants: menthol cigarette (MC), non-menthol cigarette with synthetic coolants (NMC+SC), and non-menthol cigarette control (NMC). Data on participants’ puffing behavior and the subjective effects of the products will be collected for each session. In Phase 3, participants will be instructed to replace their UBMC with their preferred study product from Phase 2 and report daily usage and perceptions for a week to assess substitution and perceived subjective effects. This Tobacco Regulatory K01 project will yield much-needed evidence on the abuse liability and substitutability of synthetic coolants for menthol in cigarettes, while providing valuable training to a promising new investigator with guidance from leading experts in the field of tobacco regulatory science.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $185,837 )
2026	2026	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	2	7/31/2026	NON-COMPETING CONTINUATION	$185,837
														Subtotal = $185,837

Issue Date FY: 2025 ( Subtotal = $186,281 )
2025	2025	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	1	7/28/2025	NEW	$186,281
2025	2025	OHIO STATE UNIVERSITY, THE	1960 KENNY RD	COLUMBUS	OH	43210	FRANKLIN	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	001	1	8/28/2025	NEW	$0
														Subtotal = $186,281

Grand Total All Awards = $372,118

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Impact of Synthetic Coolants vs. Menthol in Cigarettes on Abuse Liability and Use Behaviors

Award Number: K01DA061444

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/01/2025

PERIOD OF PERFORMANCE END DATE: 07/31/2030

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