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Pubertal development, stress system functioning, and addiction vulnerability

Award Number: K01DA060991
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/2025
PERIOD OF PERFORMANCE END DATE: 06/30/2030

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Pubertal development, stress system functioning, and addiction vulnerability - PROJECT SUMMARY The proposed career development application aims to provide research training for Dr. Elizabeth Kwon, supporting her transition to independence as a transdisciplinary scientist. Dr. Kwon's long-term career goal is to investigate the etiological risk and protective mechanisms of addiction vulnerability, with the ultimate goal of contributing to the development of next-generation interventions. Her focus is on understanding the interplay among psychological, physiological, and social factors driving addiction vulnerability during critical developmental periods. Particularly, she is interested in stress system functioning as accumulating research suggests dysregulation in neurobehavioral systems associated with the stress response operates as a key mechanism conferring risk for addiction. This work has the potential to enhance preventive interventions by elucidating physiological pathways connecting youth development and addiction. Dr. Kwon's proposed training is structured to develop competencies in (a) multimodal assessment of stress system functioning, (b) assessment of pubertal development and its interpretation across contexts and settings, and (c) professional development. Alongside formal and informal educational experiences, Dr. Kwon will investigate the links among pubertal development, stress dysregulation, and addiction vulnerability. In this research, Dr. Kwon aims to explore the psychosocial determinants of the stress system functioning and its association with addiction vulnerability. Her near-term goal (within 5 years) is to submit a competitive R01 application to the National Institute on Drug Abuse (NIDA) for a prospective study investigating the transactions among childhood adversity, pubertal maturation, trajectories of changes in stress system functioning, psychosocial environments, and adolescents’ addiction vulnerability. The proposed proof-of-principal study is intended to provide a focal point for training and preliminary data to support a competitive R01 application.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $193,789 )
2025	2025	BAYLOR UNIVERSITY	700 S UNIVERSITY PARKS DR	WACO	TX	76706	MCLENNAN	USA	Drug Use and Addiction Research Programs	000	1	6/30/2025	NEW	$193,789
														Subtotal = $193,789

Grand Total All Awards = $193,789

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Pubertal development, stress system functioning, and addiction vulnerability

Award Number: K01DA060991

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/2025

PERIOD OF PERFORMANCE END DATE: 06/30/2030

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