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Sex Differences in E-Cigarette Flavor Sensory Perception As It Relates to Appeal and Reinforcing Efficacy Among Adult Smokers

Award Number: K01DA056494
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/15/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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Sex Differences in E-Cigarette Flavor Sensory Perception As It Relates to Appeal and Reinforcing Efficacy Among Adult Smokers - Project Summary Female cigarette smokers have been shown to be more sensitive than males to non-nicotine sensory cues, which may explain lower rates of smoking cessation and lowered response to nicotine replacement therapies among females. Additionally, evidence suggests females have higher use of non-tobacco e-cigarette flavors and value flavor availability. This proposal seeks to elucidate how sex may influence the sensory perception of the popular e-cigarette flavor components, sweetness and cooling, and how this impacts appeal and reinforcing efficacy. We plan to examine sensory perception, appeal, reinforcing efficacy of three e-cigarette flavors (sweet flavor, cooling flavor, and unflavored) in an e-cigarette with moderate nicotine concentration when presented alone (Aim 1) and concurrently with or without nicotine (Aim 2). We hypothesize that compared to an unflavored e- cigarette liquid, sweet and cooling flavor components will be generally rated as more appealing and reinforcing among both males and females, but females will have more pronounced differences in appeal and reinforcing efficacy of sweet and cooling flavors compared to the unflavored e-liquid (Aim 1). Additionally, we hypothesize that males compared to females will work harder and demonstrate greater abuse liability for nicotine containing menthol e-liquids in when concurrently available with menthol e-cigarettes with no nicotine (Aim 2). The outcomes of this project will provide new information about how the difference in response by sex to the non-nicotine sensory cues of flavor inform e-cigarette use and behavior. Regulatory efforts to restrict popular flavor components, like sweet and/or cooling flavors in e-cigarettes may have potentially a greater impact on female cigarette smokers than males on use of e-cigarettes as a potential harm reduction tool. Through expert mentoring, directed readings, formal coursework and seminars, direct experimental training, attendance at scientific meetings, manuscript and grant preparation, expertise to conduct the proposed research will be gained in the following areas: (1) chemosensory psychophysics as it relates to tobacco regulatory science, (2) sex-related research as it relates to tobacco regulatory science, and (3) advanced statistical training aimed at developing data analysis techniques to investigate sex differences & flavored tobacco product use. Taken together, this research project and training plan will provide an important framework for career development in tobacco regulatory science.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $178,419 )
2026	2026	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	5	7/14/2026	NON-COMPETING CONTINUATION	$178,419
														Subtotal = $178,419

Issue Date FY: 2025 ( Subtotal = $178,419 )
2025	2025	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	002	4	7/15/2025	NON-COMPETING CONTINUATION	$178,419
2025	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	3	12/9/2024	NON-COMPETING CONTINUATION	$0
2025	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	001	3	1/13/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $178,419

Issue Date FY: 2024 ( Subtotal = $178,419 )
2024	2024	YALE UNIV	150 MUNSON ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	3	6/25/2024	NON-COMPETING CONTINUATION	$178,419
														Subtotal = $178,419

Issue Date FY: 2023 ( Subtotal = $251,806 )
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Drug Use and Addiction Research Programs	001	2	6/23/2023	SUPPLEMENT FOR EXPANSION	$73,387
2023	2023	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	2	6/16/2023	NON-COMPETING CONTINUATION	$178,419
														Subtotal = $251,806

Issue Date FY: 2022 ( Subtotal = $178,419 )
2022	2022	YALE UNIVERSITY	105 WALL ST	NEW HAVEN	CT	06511	SOUTH CENTRAL CT	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	1	7/8/2022	NEW	$178,419
														Subtotal = $178,419

Grand Total All Awards = $965,482

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Sex Differences in E-Cigarette Flavor Sensory Perception As It Relates to Appeal and Reinforcing Efficacy Among Adult Smokers

Award Number: K01DA056494

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/15/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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