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Perinatal care as a venue to reduce opioid overdoses and hepatitis C virus incidence (PreVenT OD HCV)

Award Number: K01DA052821
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/2022
PERIOD OF PERFORMANCE END DATE: 06/30/2027

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Perinatal care as a venue to reduce opioid overdoses and hepatitis C virus incidence (PreVenT OD HCV) - PROJECT SUMMARY/ABSTRACT Amidst the current opioid overdose crisis, 1.4 million women of reproductive age report non-medical opioid use, and opioid use disorder (OUD) prevalence among pregnant women rose five-fold from 1998-2017. Although pregnancy may be a motivating time to start medications to treat OUD, retention post-partum declines significantly and is associated with unacceptably high opioid overdose and mortality rates. Injection drug use is also the primary risk factor for hepatitis C virus (HCV) infection in the United States (U.S.). Women now comprise nearly half of new HCV infections, and HCV seroprevalence has also risen five-fold in pregnant women since 2000. Although the U.S. is committed to eliminating HCV, about 50% of people are unaware of their infection and fewer than 40% of those diagnosed have been treated. Research is needed to identify venues to increase efforts to improve OUD treatment and retention and to identify and treat current HCV infection. Perinatal care provides longitudinal access to women over a nearly one-year period, and as pregnancy may be a motivating time for women to seek care for both OUD and HCV, perinatal care may be a critical venue to reach women who inject drugs, a key population that NIDA identifies as central to the ongoing opioid crisis. Yet, little data exist to measure the role of the perinatal care venue to reach national OUD and HCV treatment goals. This study aims to create a perinatal-specific decision model and measure health service utilization and costs of a perinatal OUD and HCV intervention to identify how to leverage the perinatal care venue to decrease postpartum opioid overdoses and population-level HCV transmission. This study has two main aims: (1) to build a microsimulation model to analyze the clinical and health economic effects of leveraging the perinatal care venue to reduce opioid overdoses and population-level and infant HCV transmission; (2) to measure health services utilization and costs of incorporating MOUD and HCV treatment into perinatal care. The results of this study could help determine most efficient resource allocation to achieve national overdose and HCV elimination goals. The PI, Dr. Epstein, is an early career investigator, trained in pediatric and adult infectious diseases, with a focus on addiction medicine and HCV in pregnant women and youth. This career development award will allow her to gain expertise in 1) transmission modeling and model calibration and 2) health economic evaluation and micro-costing to be able to conduct comparative cost-effectiveness research to inform interventions for women with substance use and HCV. She has compiled an experienced team of mentors and advisors to help her achieve her training and career goals, to become an independent clinician-investigator expert in utilizing decision science to project most effective use of resources to improve care for families at the center of the opioid overdose, HCV and HIV epidemics.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $189,216 )
2025	2025	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL	BOSTON	MA	02118	SUFFOLK	USA	Drug Use and Addiction Research Programs	001	4	7/17/2025	NON-COMPETING CONTINUATION	$189,216
2025	2024	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL	BOSTON	MA	02118	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	3	3/28/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $189,216

Issue Date FY: 2024 ( Subtotal = $229,691 )
2024	2024	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL	BOSTON	MA	02118	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	3	7/11/2024	NON-COMPETING CONTINUATION	$175,694
2024	2024	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL	BOSTON	MA	02118	SUFFOLK	USA	Drug Use and Addiction Research Programs	001	3	7/25/2024	SUPPLEMENT FOR EXPANSION	$53,997
														Subtotal = $229,691

Issue Date FY: 2023 ( Subtotal = $175,382 )
2023	2023	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL STE 1	BOSTON	MA	02118	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	2	6/2/2023	NON-COMPETING CONTINUATION	$175,382
														Subtotal = $175,382

Issue Date FY: 2022 ( Subtotal = $175,574 )
2022	2022	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL STE 1	BOSTON	MA	02118	SUFFOLK	USA	Drug Use and Addiction Research Programs	000	1	5/11/2022	NEW	$175,574
														Subtotal = $175,574

Grand Total All Awards = $769,863

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Perinatal care as a venue to reduce opioid overdoses and hepatitis C virus incidence (PreVenT OD HCV)

Award Number: K01DA052821

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/2022

PERIOD OF PERFORMANCE END DATE: 06/30/2027

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