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Neuroimaging approaches to improve prediction of smoking initiation and nicotine use escalation among young adult electronic nicotine delivery systems users

Award Number: K01DA049292
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

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PROJECT SUMMARY/ABSTRACT The proposed career development application provides research training for Dr. Jiaying Liu to facilitate her transition to independence. The goal of the proposed research is to identify neurobehavioral makers of nicotine use escalation and cigarette smoking initiation among young adult (YA) users of electronic nicotine delivery systems (ENDS). Findings are expected to inform regulatory policy and improve YA responsiveness to public health campaign communications. Given the accumulating evidence that ENDS use conveys 5-fold additional risk for smoking initiation and other tobacco use escalation, recent YA increases in use are alarming, threatening a resurgence of dependence that may reverse decades of tobacco control success. Therefore, it is crucial to identify predictive markers of smoking initiation and tobacco use escalation in this vulnerable population, and to provide actionable evidence that informs regulatory and prevention efforts. Functional magnetic resonance imaging (fMRI) generates information complementary to traditional behavioral risk assessments, with direct observations of the neural substrates that underlie the subjective states known to perpetuate addiction, in order to yield objective and putatively more predictive measures. Assessment of behavioral and brain markers associated with smoking onset and tobacco use escalation is proposed. The goal is to determine whether baseline neurobehavioral markers will predict smoking transition and tobacco use escalation beyond traditional makers at 3, 6, 9 and 12 months. A one-year public service announcement (PSA) intervention with a cross-over design will also be conducted, in which two message exposure orders and one control condition allow testing whether novel anti-ENDS PSAs addressing harms associated with ENDS flavors will more effectively prevent tobacco use escalation compared to the existing regular PSAs. The proposed research is among the first that aims to inform regulation of flavored ENDS marketing, and to provide recommendations for developing effective PSAs for prevention campaigns. These aims directly address multiple priorities of FDA Center for Tobacco Products (Marketing Influences, Communications, Behavior and Addiction), and they are expected to pinpoint effective regulatory gates to address the current ENDS epidemic. Dr. Liu’s long-term goal is to become an independent researcher translating communication neuroscience research to regulatory actions for improvements in health campaigns and interventions utilizing persuasive anti-tobacco messaging. Her near-term goal is to prepare a competitive R01 application to implement randomized controlled trials of PSAs to maximize impact on deterrence of smoking and substance use transition among ENDS users. The proposed training experience is designed to develop competencies in (a) neuroscience, (b) functional neuroimaging, (c) tobacco regulatory science, and (d) grant writing. The proposed research study provides focus for training and preliminary data to support a competitive R01 application.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $158,137 )
2024	2024	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	004	5	8/30/2024	NON-COMPETING CONTINUATION	$158,137
2024	2023	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	003	4	3/4/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2024	2023	"UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	002	4	11/17/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$0
2024	2023	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	001	4	11/7/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$49,610
2024	2022	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 E CAMPUS RD RM 409	ATHENS	GA	30602	CLARKE	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	3	11/7/2023	NON-COMPETING CONTINUATION	-$49,610
														Subtotal = $158,137

Issue Date FY: 2023 ( Subtotal = $177,789 )
2023	2023	UNIVERSITY OF CALIFORNIA, SANTA BARBARA	3227 CHEADLE HALL	SANTA BARBARA	CA	93106	SANTA BARBARA	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	002	4	8/30/2023	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$177,789
2023	2022	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	3	2/21/2023	NON-COMPETING CONTINUATION	$0
2023	2022	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	001	3	8/30/2023	NON-COMPETING CONTINUATION	$0
														Subtotal = $177,789

Issue Date FY: 2022 ( Subtotal = $180,851 )
2022	2022	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	001	3	8/24/2022	NON-COMPETING CONTINUATION	$180,851
2022	2021	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	2	12/14/2021	NON-COMPETING CONTINUATION	$0
														Subtotal = $180,851

Issue Date FY: 2021 ( Subtotal = $180,851 )
2021	2021	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	2	8/25/2021	NON-COMPETING CONTINUATION	$180,851
														Subtotal = $180,851

Issue Date FY: 2020 ( Subtotal = $174,029 )
2020	2020	UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.	310 EAST CAMPUS RD TUCKER HALL ROOM 409	ATHENS	GA	30602	CLARKE	USA	Family Smoking Prevention and Tobacco Control Act Regulatory Research	000	1	8/5/2020	NEW	$174,029
														Subtotal = $174,029

Grand Total All Awards = $871,657

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Neuroimaging approaches to improve prediction of smoking initiation and nicotine use escalation among young adult electronic nicotine delivery systems users

Award Number: K01DA049292

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

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