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Multi-method signature of risk for compulsive substance use: Human translation of the incentive-sensitization model

Award Number: K01DA044270
ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 02/15/2019
PERIOD OF PERFORMANCE END DATE: 01/31/2025

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Multi-method signature of risk for compulsive substance use: Human translation of the incentive-sensitization model - PROJECT SUMMARY/ABSTRACT The purpose of this K01 award is to advance the career of the candidate (Dr. Lora Cope) by providing the specialized training she needs in key components of behavioral addiction research, neuroimaging, and statistics. In pursuit of this goal, Dr. Cope will work closely with her carefully selected mentorship team at the University of Michigan, who will provide mentorship in three critical training domains: 1) incentive- sensitization theory of addiction and Pavlovian conditioned approach, 2) neuroimaging study development and implementation, and 3) advanced multivariate statistics. Training will consist of courses, mentor meetings, workshops, scientific meetings, experiential learning, and other activities as described in the Plan for Career Development. Dr. Cope's short-term career goal is to study impulsive choice- and cue reactivity-based individual differences for addiction liability from an incentive-sensitization perspective (see Specific Aims) while receiving the training outlined in this proposal. Her long-term career goal is to hold a tenure-track academic position in the field of addiction neuroimaging, conducting important and clinically meaningful translational research on individual differences for addiction liability. The research proposed in this application will not only facilitate this training, but also advance understanding of compulsive substance use and substance use disorder liability in adolescents transitioning to adulthood. The incentive-sensitization framework developed at the University of Michigan draws a critical distinction between “sign tracking” and “goal tracking” responses. It is an extensively studied and supported animal model of addiction, and the proposed research builds on promising attempts to translate this framework to humans. This work will delineate the multi-method signature of incentive salience attribution in humans by measuring 1) sign- tracking and goal-tracking using a Pavlovian conditioned approach paradigm, 2) neurobiological circuitry involved in impulsive choice and cue reactivity using functional magnetic resonance imaging, 3) trait constructs correlated with substance use, and 4) substance use outcomes. The project will study 92 participants with low to moderate levels of alcohol and/or marijuana use, aged 16–18 at the time of baseline assessment. Participants will be followed over 2.5 years for detailed substance use and behavioral assessment. This work will address the following research aims: 1) Delineate the neural signature of incentive salience attribution, and 2) Identify longitudinal multi-method predictors of substance use outcomes. The long- term objective of this work is to use detailed understanding of the brain mechanisms of incentive salience to construct objective biomarkers to guide diagnosis and treatment of substance use disorders, with the ultimate goals of limiting transition to compulsive use, reducing relapse, and improving human health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	1109 GEDDES AVE STE 3300	ANN ARBOR	MI	48109	WASHTENAW	USA	Drug Use and Addiction Research Programs	000	5	5/1/2025	NON-COMPETING CONTINUATION	$0
														Subtotal = $0

Issue Date FY: 2023 ( Subtotal = $166,817 )
2023	2023	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON STREET	ANN ARBOR	MI	48109	WASHTENAW	USA	Drug Use and Addiction Research Programs	000	5	1/20/2023	NON-COMPETING CONTINUATION	$166,817
														Subtotal = $166,817

Issue Date FY: 2022 ( Subtotal = $166,857 )
2022	2022	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Drug Use and Addiction Research Programs	000	4	1/13/2022	NON-COMPETING CONTINUATION	$166,857
														Subtotal = $166,857

Issue Date FY: 2021 ( Subtotal = $166,905 )
2021	2021	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Drug Use and Addiction Research Programs	000	3	1/28/2021	NON-COMPETING CONTINUATION	$166,905
														Subtotal = $166,905

Issue Date FY: 2020 ( Subtotal = $166,905 )
2020	2020	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Drug Use and Addiction Research Programs	000	2	1/27/2020	NON-COMPETING CONTINUATION	$166,905
														Subtotal = $166,905

Issue Date FY: 2019 ( Subtotal = $167,079 )
2019	2019	REGENTS OF THE UNIVERSITY OF MICHIGAN	503 THOMPSON ST	ANN ARBOR	MI	48109	WASHTENAW	USA	Drug Use and Addiction Research Programs	000	1	2/14/2019	NEW	$167,079
														Subtotal = $167,079

Grand Total All Awards = $834,563

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Multi-method signature of risk for compulsive substance use: Human translation of the incentive-sensitization model

Award Number: K01DA044270

ORGANIZATION: NATIONAL INSTITUTE ON DRUG ABUSE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 02/15/2019

PERIOD OF PERFORMANCE END DATE: 01/31/2025

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