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Linking Symptom Screening to Electronic Health Record-Integrated Care Pathways for Children with Cancer: the LISTEN Intervention

Award Number: K01CA317043
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/01/2026
PERIOD OF PERFORMANCE END DATE: 08/31/2031

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Linking Symptom Screening to Electronic Health Record-Integrated Care Pathways for Children with Cancer: the LISTEN Intervention - PROJECT SUMMARY/ABSTRACT Almost all children undergoing cancer treatment experience bothersome symptoms that lead to suffering and poor quality of life. In a 20-center randomized trial, routine patient-reported outcome (PRO) symptom screening and linked symptom management care pathways yielded a significant reduction in symptom severity compared to controls. While effective, two key gaps remain including lack of integration with the electronic health record (EHR) and limited uptake of evidence-based treatments. In this K01 we will adapt this effective intervention and identify clinical and EHR-based strategies for the core goals of LISTEN (Linking Symptom Screening to EHR-Integrated Care Pathways): a) delivering symptom screening results and flagging bothersome symptoms, b) guiding clinicians to act on symptoms using evidence-based care pathways, and c) documenting symptoms and treatment. This proposal targets fatigue, altered cognition, and appetite changes, highly prevalent, distressing, and actionable symptoms for which only 0-8% of children receive treatment. This K01 will build on Dr. L’Hotta’s prior work integrating a fatigue PRO into the EHR and expands to multi-symptom screening. Dr. L’Hotta’s overarching hypothesis is that LISTEN will improve PRO symptom screening and management and reduce symptom severity in children. The specific aims of this proposal are to: 1) apply human-centered design with key partners to refine clinical and EHR delivery strategies for LISTEN’s clinical integration; 2) conduct a single-arm pilot feasibility trial of LISTEN and explore implementation outcomes and effectiveness on reducing symptom severity; and 3) co-create an implementation guide with 2 pediatric oncology sites to proactively plan adaptations to LISTEN for future multi-site testing. In alignment with these research aims, Dr. L’Hotta will engage in targeted training in 1) human-centered design for EHR embedded interventions, 2) planning outcome assessments in pragmatic trials, and 3) application of co-creation principles in pediatric oncology trials. This K01 is essential to support Dr. L’Hotta’s transition from descriptive and observational research to rigorous intervention development and pragmatic clinical trials. Dr. L’Hotta’s long-term goal of becoming an independent interventionist focused on improving the health and quality of life of children with cancer hinges on acquiring this focused training. The University of Colorado Anschutz Medical Campus, along with its NCI- designated Comprehensive Cancer Center and the Adult and Child Center for Health Outcomes Research and Delivery Science, offer a rich environment to engage in training and conduct cancer-focused research. Dr. L’Hotta’s exceptional team of mentors and content advisors with expertise in pediatric oncology supportive care, dissemination and implementation science, human-centered design, pragmatic clinical trials, and partner- engaged approaches will support this K01. Completion of the proposed research and training aims will position Dr. L’Hotta as an independent clinician scientist who uses innovative, partner-engaged approaches to design interventions that reduce cancer-related morbidity and improve quality of life among children with cancer.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $189,653 )
2026	2026	THE REGENTS OF THE UNIVERSITY OF COLORADO	13001 E 17TH PL STE F428	AURORA	CO	80045	ADAMS	USA	Cancer Research Manpower	000	1	8/6/2026	NEW	$189,653
														Subtotal = $189,653

Grand Total All Awards = $189,653

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Linking Symptom Screening to Electronic Health Record-Integrated Care Pathways for Children with Cancer: the LISTEN Intervention

Award Number: K01CA317043

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/01/2026

PERIOD OF PERFORMANCE END DATE: 08/31/2031

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