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Effect of Lumbar Hypo & Hypermobility on Sensory Responses to Spinal Manipulation

Award Number: K01AT005935
ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/01/2010
PERIOD OF PERFORMANCE END DATE: 08/31/2016

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Effect of Lumbar Hypo & Hypermobility on Sensory Responses to Spinal Manipulation - DESCRIPTION (provided by applicant): Manual therapy practitioners frequently include assessment of spinal joint mobility in their clinical examination and treatment of patients with low back pain. There is increasing evidence that clinical identification of spinal joint hypo- and hypermobility subgroups along with correspondingly tailored manual therapy treatment approaches can lead to more successful therapeutic outcomes. For example, individuals with low back pain and spinal hypomobility have been shown to respond better to spinal manipulation than those with spinal joint hypermobility. What underlying biological/neural mechanisms could be responsible for the different clinical responses from these subgroups when treated with spinal manipulation? This question motivates this career development plan which allows the candidate to accomplish his immediate goals of: a) working with an animal model that combines simulated spinal manipulation with peripheral neural recordings from lumbar paraspinal muscles and b) attaining knowledge of musculoskeletal biomechanics pertinent to the applied spinal loading that occurs during spinal manipulation through didactic coursework. In this study, an established cat lumbar spine model will be used to determine the effects of proximal, distal, and bi-segmental spinal joint hypo- and hypermobility on paraspinal muscle spindle discharge during simulated high velocity low amplitude spinal manipulation of different durations (25-400ms). Spinal joint hypomobility will be created by placing unilateral bone screws through the facet joint; hypermobility will be created via unilateral facetectomies. This study will reveal relationships between spinal joint dysfunction and sensory feedback related to a specific manual therapy intervention (spinal manipulation) with demonstrated effectiveness in the treatment of low back pain. By adding spinal joint hypo- and hypermobility conditions to an established animal model used to investigate spinal manipulation, this career development award provides the candidate with tools and experience to accomplish his long-term career goal of determining how spinal manipulation in the presence of spinal joint dysfunction affects the central nervous system. The candidate is a second generation chiropractor and this career development plan will be completed at the largest chiropractic research center in the world (Palmer Center for Chiropractic Research) which recently received a NIH/NCCAM grant to establish a four year multi-disciplinary Developmental Center for Clinical and Translational Science.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2017 ( Subtotal = -$2,968 )
2017	2014	PALMER COLLEGE FOUNDATION	1000 BRADY ST	DAVENPORT	IA	52803	SCOTT	USA	Research and Training in Complementary and Integrative Health	000	5	1/9/2017	NON-COMPETING CONTINUATION	-$2,968
														Subtotal = -$2,968

Issue Date FY: 2014 ( Subtotal = $132,382 )
2014	2014	PALMER COLLEGE OF CHIROPRACTIC	1000 BRADY STREET	DAVENPORT	IA	52803	SCOTT	USA	Research and Training in Complementary and Integrative Health	000	5	7/28/2014	NON-COMPETING CONTINUATION	$132,382
														Subtotal = $132,382

Issue Date FY: 2013 ( Subtotal = $128,205 )
2013	2013	PALMER COLLEGE OF CHIROPRACTIC	1000 BRADY STREET	DAVENPORT	IA	52803	SCOTT	USA	Research and Training in Complementary and Integrative Health	000	4	7/25/2013	NON-COMPETING CONTINUATION	$128,205
														Subtotal = $128,205

Issue Date FY: 2012 ( Subtotal = $128,339 )
2012	2012	PALMER COLLEGE OF CHIROPRACTIC	1000 BRADY STREET	DAVENPORT	IA	52803	SCOTT	USA	Research and Training in Complementary and Integrative Health	000	3	8/24/2012	NON-COMPETING CONTINUATION	$128,339
														Subtotal = $128,339

Issue Date FY: 2011 ( Subtotal = $125,473 )
2011	2011	PALMER COLLEGE OF CHIROPRACTIC	1000 BRADY STREET	DAVENPORT	IA	52803	SCOTT	USA	Research and Training in Complementary and Integrative Health	000	2	8/19/2011	NON-COMPETING CONTINUATION	$125,473
														Subtotal = $125,473

Issue Date FY: 2010 ( Subtotal = $123,336 )
2010	2010	PALMER COLLEGE OF CHIROPRACTIC	1000 BRADY STREET	DAVENPORT	IA	52803	SCOTT	USA	Research and Training in Complementary and Integrative Health	000	1	5/20/2010	NEW	$123,336
2010	2010	PALMER COLLEGE OF CHIROPRACTIC	1000 BRADY STREET	DAVENPORT	IA	52803	SCOTT	USA	Research and Training in Complementary and Integrative Health	001	1	6/14/2010	NEW	$0
														Subtotal = $123,336

Grand Total All Awards = $634,767

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Effect of Lumbar Hypo & Hypermobility on Sensory Responses to Spinal Manipulation

Award Number: K01AT005935

ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/01/2010

PERIOD OF PERFORMANCE END DATE: 08/31/2016

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