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PRECLINICAL STUDIES OF CAM BOTANICALS AND IRON OVERLOAD

Award Number: K01AT003448
ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/15/2008
PERIOD OF PERFORMANCE END DATE: 05/31/2013

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PRECLINICAL STUDIES OF CAM BOTANICALS AND IRON OVERLOAD - DESCRIPTION (provided by applicant): Natural botanical substances are increasingly used for medicinal purposes in the U.S.; many Americans use these types of alternative medicines for disease prevention or therapy. The need to document and characterize these products creates a strong demand for scientists trained in biologically based practices of Complementary and Alternative Medicine (CAM). The candidate, Dr. Donald J. Messner, is an experienced biomedical scientist developing a research program in CAM botanicals at Bastyr University. Training for Dr. Messner will focus on preclinical characterization of botanical substances, with emphasis on botanical science, analytical chemistry, animal models of liver disease, and proteomics. An expert group of advisors has been recruited to this effort from three closely aligned institutions in the Seattle area: Bastyr University, the University of Washington, and the Fred Hutchinson Cancer Research Center. The advisory team will be guided by Dr. Kris V. Kowdley, a Hepatologist at Virginia Mason Hospital and the University of Washington and an expert in iron and liver disorders. The research plan consists of a comprehensive preclinical assessment of turmeric, the common food ingredient derived from C. longa, for iron overload and prevention of liver cancer. The specific aims are as follows: Aim 1. To document the antioxidant capacity and iron binding properties of turmeric. Aim 2. To determine effects, evaluate mechanisms, and identify biomarkers of turmeric related to prevention of in vitro transformation of iron-loaded liver cells. Aim 3. To determine effects and identify biomarkers of turmeric on iron-related hepatocarcinogenesis in mice. This project has the long-term goal of improving human health by reducing the impact of iron in liver diseases including hepatocellular carcinoma. It may be anticipated that upon completion of this training, the candidate will be expertly prepared for investigating other biologically based practices of CAM in liver disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2012 ( Subtotal = $128,580 )
2012	2012	BASTYR UNIVERSITY	14500 JUANITA DRIVE NE	BOTHELL	WA	98011	KING	USA	Research and Training in Complementary and Integrative Health	000	5	5/7/2012	NON-COMPETING CONTINUATION	$128,580
														Subtotal = $128,580

Issue Date FY: 2011 ( Subtotal = $128,580 )
2011	2011	BASTYR UNIVERSITY	14500 JUANITA DRIVE NE	BOTHELL	WA	98011	KING	USA	Research and Training in Complementary and Integrative Health	000	4	4/4/2011	NON-COMPETING CONTINUATION	$128,580
														Subtotal = $128,580

Issue Date FY: 2010 ( Subtotal = $126,878 )
2010	2010	BASTYR UNIVERSITY	14500 JUANITA DRIVE NE	BOTHELL	WA	98011	KING	USA	Research and Training in Complementary and Integrative Health	000	3	5/17/2010	NON-COMPETING CONTINUATION	$126,878
														Subtotal = $126,878

Issue Date FY: 2009 ( Subtotal = $124,040 )
2009	2009	BASTYR UNIVERSITY	14500 JUANITA DRIVE NE	BOTHELL	WA	98011	KING	USA	Research and Training in Complementary and Integrative Health	000	2	4/21/2009	NON-COMPETING CONTINUATION	$124,040
														Subtotal = $124,040

Issue Date FY: 2008 ( Subtotal = $121,190 )
2008	2008	BASTYR UNIVERSITY	14500 JUANITA DRIVE NE	BOTHELL	WA	98011	KING	USA	Research and Training in Complementary and Integrative Health	000	1	9/26/2008	NEW	$121,190
														Subtotal = $121,190

Grand Total All Awards = $629,268

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PRECLINICAL STUDIES OF CAM BOTANICALS AND IRON OVERLOAD

Award Number: K01AT003448

ORGANIZATION: CENTER FOR DRUG EVALUATION AND RESEARCH, NIH

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/15/2008

PERIOD OF PERFORMANCE END DATE: 05/31/2013

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