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Modulating Fibro/Adipogenic Precursors to Prevent Adipogenic Replacement of Muscle

Award Number: K01AR077686
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 05/21/2021
PERIOD OF PERFORMANCE END DATE: 04/30/2026

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Modulating Fibro/Adipogenic Precursors to Prevent Adipogenic Replacement of Muscle - ABSTRACT. Successful muscle regeneration requires an elaborate cellular choreography between multiple cell populations to remove and replace damaged fibers. Disruption of this choreography leads to muscle degeneration and fibrotic or adipogenic replacement of myofibers. This phenomenon is particularly prevalent in muscular dystrophies, where progressive muscle loss leads to severe debilitation and early loss of life. Hence, there is growing need to understand the cell populations and their interactions which contribute to myofiber regeneration, but can lead to fibrotic or adipogenic replacement when gone awry. This project aims to understand the mechanism underlying impaired cellular interactions leading to myofiber loss and muscle weakness in limb girdle muscular dystrophy type 2B and test approaches to prevent this impairment. This understanding will help develop novel targeted therapeutic approaches to arrest disease progression in this and other muscular dystrophies that are currently without effective treatment options.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $99,342 )
2025	2025	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	5/6/2025	NON-COMPETING CONTINUATION	$99,342
														Subtotal = $99,342

Issue Date FY: 2024 ( Subtotal = $99,342 )
2024	2024	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	5/15/2024	NON-COMPETING CONTINUATION	$99,342
														Subtotal = $99,342

Issue Date FY: 2023 ( Subtotal = $99,342 )
2023	2023	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	4/10/2023	NON-COMPETING CONTINUATION	$99,342
														Subtotal = $99,342

Issue Date FY: 2022 ( Subtotal = $99,342 )
2022	2022	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	5/4/2022	NON-COMPETING CONTINUATION	$99,342
														Subtotal = $99,342

Issue Date FY: 2021 ( Subtotal = $99,342 )
2021	2021	CHILDREN'S RESEARCH INSTITUTE	111 MICHIGAN AVE NW	WASHINGTON	DC	20010	DISTRICT OF COLUMBIA	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	5/21/2021	NEW	$99,342
														Subtotal = $99,342

Grand Total All Awards = $496,710

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Modulating Fibro/Adipogenic Precursors to Prevent Adipogenic Replacement of Muscle

Award Number: K01AR077686

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 05/21/2021

PERIOD OF PERFORMANCE END DATE: 04/30/2026

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