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Role of periostin expressing cells in intramembranous bone regeneration

Award Number: K01AR077679
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/01/2021
PERIOD OF PERFORMANCE END DATE: 06/30/2026

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Role of periostin expressing cells in intramembranous bone regeneration - Project Summary/Abstract: The proposal includes a comprehensive 5-year mentored career development plan for Dr. Frank Ko to transition to an independent investigator who studies intramembranous bone regeneration. The candidate is currently an assistant professor in the Department of Cell & Molecular Medicine (CMM) at Rush University Medical Center (RUMC) and conducts his research at RUMC and at its affiliated centers and institutions. He is well supported by the institution and will devote 100% of his time to his research and career development plan. The candidate has assembled mentors and a scientific advisory committee with a wide array of complementary expertise and extensive mentoring experience to offer career guidance during his transition to independent research and train him in new intellectual and technical skills for his proposed studies. His mentor, Dr. Rick Sumner, is an expert in the field of bone regeneration and implant fixation, the Chair of CMM at RUMC, and the director of Rush MicroCT/Histology Core Facility. His co-mentor, Dr. Anna Spagnoli, is a clinician-scientist with an expertise in the field of skeletal development and diseases and is the director of Section of Molecular Medicine in the Department of Orthopedic Surgery at RUMC. Scientific advisory committee member Dr. Noriaki Ono is a molecular biologist studying skeletal stem and progenitor cells. The science focuses on the role of periostin-expressing cells in intramembranous bone regeneration following marrow ablation surgery. The candidate discovered that these cells, which are normally absent in marrow and reside in the periosteum, are present in the regenerating marrow cavity following the surgery and their depletion delays intramembranous bone regeneration. Thus, the specific aims are to investigate: 1) the necessity of periostin-expressing cells and periostin in intramembranous bone regeneration; and 2) the lineage commitment, molecular signatures, and differentiation of periostin-expressing cells and their progeny during intramembranous bone regeneration. To complement his prior training in bone biomechanics and molecular biology in intact tissues, the candidate will be trained in the use of reporter mice, animal surgery, and regenerated bone phenotyping, including light sheet and expansion microscopy, gene and protein expression analyses, and in vitro culture and assay. Further, he will participate in career development activities that include didactic lectures and seminar series focusing on tissue regeneration, stem cell biology, biostatistics, grant writing, responsible conduct of research, and scientific presentation. This K01 proposal will allow the candidate to gain valuable career development mentoring to achieve his goal of becoming an independent investigator studying intramembranous bone regeneration.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $119,529 )
2025	2025	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	6/11/2025	NON-COMPETING CONTINUATION	$119,529
														Subtotal = $119,529

Issue Date FY: 2024 ( Subtotal = $119,529 )
2024	2024	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	6/21/2024	NON-COMPETING CONTINUATION	$119,529
														Subtotal = $119,529

Issue Date FY: 2023 ( Subtotal = $183,049 )
2023	2023	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	3	6/5/2023	NON-COMPETING CONTINUATION	$119,529
2023	2023	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PKWY	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	3	9/1/2023	SUPPLEMENT FOR EXPANSION	$63,520
														Subtotal = $183,049

Issue Date FY: 2022 ( Subtotal = $165,396 )
2022	2022	RUSH UNIVERSITY MEDICAL CENTER	1620 W HARRISON ST	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	6/15/2022	NON-COMPETING CONTINUATION	$119,529
2022	2022	RUSH UNIVERSITY MEDICAL CENTER	1620 W HARRISON ST	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	001	2	7/22/2022	SUPPLEMENT FOR EXPANSION	$45,867
														Subtotal = $165,396

Issue Date FY: 2021 ( Subtotal = $119,529 )
2021	2021	RUSH UNIVERSITY MEDICAL CENTER	1653 W CONGRESS PRKWY	CHICAGO	IL	60612	COOK	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	6/29/2021	NEW	$119,529
														Subtotal = $119,529

Grand Total All Awards = $707,032

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Role of periostin expressing cells in intramembranous bone regeneration

Award Number: K01AR077679

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/01/2021

PERIOD OF PERFORMANCE END DATE: 06/30/2026

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