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SPARC MODULATES EXTRACELLULAR MATRIX DYNAMICS IN SKIN

Award Number: K01AR002220
ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/15/2001
PERIOD OF PERFORMANCE END DATE: 06/30/2005

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SPARC MODULATES EXTRACELLULAR MATRIX DYNAMICS IN SKIN - This research proposal addresses the function of SPARC (secreted protein acidic and rich in cysteine) in the maintenance and repair of collagenous matrices in the skin. The motivation for these Aims is based on the observations that the skin of SPARC-null mice is lower in tensile strength than that of wild-type mice and that the tails of SPARC-null animals have curly tips. Both of these phenotypes are consistent with aberrant collagen matrices. In addition, recent data from their laboratory indicate that SPARC regulates collagen and TGF-B in renal cells and tissue. They hypothesize that SPARC serves to modulate cellular interaction with collagen-rich matrices. First, the molecular basis of skin fragility and tail abnormalties will be investigated by testing the function of SPARC in 1) collagen fibrillogenesis, 2) procollagen processing, 3) matrix metalloprotease regulation, and 4) cellular rearrangement of collagen gels. Second, the potential function of SPARC in the regulation the activity of transglutaminase, an enzyme that lends stability to the ECM by the formation of covalent crosslinks and modulates the activity of TGF-B by cross-linking the cytokine to the ECM, will be addressed. Third, how alterations in collagen fibril formation or degradation and/or changes in transglutaminase activity affect animal models of skin repair and foreign body response in SPARC-null versus wild-type animals will be investigated. These studies have the potential to contribute to the understanding of wound healing, biocompatibility, and the pathogenesis of collagen disorders such as Ehlers-Danlos Syndrome that could accelerate the progress and design of new therapies in the treatment and resolution of these events.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2004 ( Subtotal = $111,405 )
2004	2004	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29425	CHARLESTON	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	5	6/30/2004	NON-COMPETING CONTINUATION	$111,405
														Subtotal = $111,405

Issue Date FY: 2003 ( Subtotal = $108,161 )
2003	2003	MEDICAL UNIVERSITY OF SOUTH CAROLINA	19 HAGOOD AVE, SUITE 608	CHARLESTON	SC	29425	CHARLESTON	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	4	9/12/2003	NON-COMPETING CONTINUATION	$108,161
														Subtotal = $108,161

Issue Date FY: 2002 ( Subtotal = $105,011 )
2002	2002	THE HOPE HEART INSTITUTE	556 18TH AVENUE	SEATTLE	WA	98122	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	2	6/28/2002	NON-COMPETING CONTINUATION	$105,011
														Subtotal = $105,011

Issue Date FY: 2001 ( Subtotal = $101,952 )
2001	2001	THE HOPE HEART INSTITUTE	556 18TH AVENUE	SEATTLE	WA	98122	KING	USA	Arthritis, Musculoskeletal and Skin Diseases Research	000	1	7/10/2001	NEW	$101,952
														Subtotal = $101,952

Grand Total All Awards = $426,529

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SPARC MODULATES EXTRACELLULAR MATRIX DYNAMICS IN SKIN

Award Number: K01AR002220

ORGANIZATION: NATIONAL INSTITUTE OF ARTHRITIS & MUSCULOSKELETAL & SKIN DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/15/2001

PERIOD OF PERFORMANCE END DATE: 06/30/2005

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