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Surveillance and Risk Prioritization of Bat-Borne Paramyxoviruses

Award Number: K01AI201805
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/14/2026
PERIOD OF PERFORMANCE END DATE: 07/31/2030

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Surveillance and Risk Prioritization of Bat-Borne Paramyxoviruses - PROJECT SUMMARY/ABSTRACT Emerging zoonotic viruses pose an increasing threat to human and animal health, yet our ability to forecast which viruses are most likely to spill over remains limited. Most prioritization frameworks rely heavily on expert opinion and epidemiological risk factors, while lacking empirical viral trait data that directly influence spillover, such as host cell entry. Paramyxoviruses are of particular concern, given their history of cross-species transmission and repeated emergence (e.g., Hendra and Nipah viruses), yet little is known about their traits and ecological contexts that shape their emergence in the Neotropics. Through two integrated aims, this project will investigate paramyxoviruses circulating in bats in Puerto Rico. Aim 1 will develop pseudotyped viral reagents (rVSVs) and stably transfected cell lines to quantify the entry potential of these viruses across receptors for co-roosting bat, livestock, and human. Aim 2 will use longitudinal surveillance to identify temporal windows of viral shedding, assess ecological factors such as reproductive cycles and spatial overlap among host species, and evaluate opportunities for cross-species transmission, including interactions with other mammals such as pigs. Together, these data will identify the viral traits and ecological conditions that elevate spillover risk. Outputs will feed directly in risk characterization (e.g., CEPI’s VISTA) and pandemic intelligence initiatives (e.g., NSF-CPI) to ensure findings translate into actionable tools for pandemic preparedness. In addition to the scientific impact, this award will provide Dr. Bonavita with mentored experience in molecular virology and ecological field surveillance. Under the guidance of experts in viral ecology, molecular virology, and pandemic preparedness, she will gain the skills, professional networks, and preliminary data necessary to launch an independent research program at the interface of virology and ecology.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $205,956 )
2026	2026	UNIVERSITY OF CALIFORNIA, DAVIS	1850 RESEARCH PARK DR STE 300	DAVIS	CA	95618	YOLO	USA	Allergy and Infectious Diseases Research	000	1	8/14/2026	NEW	$205,956
														Subtotal = $205,956

Grand Total All Awards = $205,956

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Surveillance and Risk Prioritization of Bat-Borne Paramyxoviruses

Award Number: K01AI201805

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/14/2026

PERIOD OF PERFORMANCE END DATE: 07/31/2030

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