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Investigating SARS-CoV-2 transmission dynamics in jails to address the COVID-19 public health emergency

Award Number: K01AI171088
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 08/22/2022
PERIOD OF PERFORMANCE END DATE: 07/31/2027

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Investigating SARS-CoV-2 transmission dynamics in jails to address the COVID-19 public health emergency - ABSTRACT Throughout the SARS-CoV-2 pandemic, explosive transmission of infection has occurred in jails and prisons. The spillover of infection between jails, prisons, and surrounding communities is fueled by high churn of the incarcerated population and daily cycling of correctional staff between facility and community. Failure to control transmission in correctional settings has resulted in significant COVID-19 morbidity and mortality and contributed to continuing racial health disparities. Despite emerging evidence of disproportionate spread of SARS-CoV-2 infection arising from jails and prisons, few studies have examined transmission dynamics in correctional settings or evaluated interventions to reduce COVID-19 morbidity and mortality. The objective of this Mentored Research Scientist Development Award (K01) is to equip Dr. Levintow with essential training in criminal justice research and infectious disease modeling to investigate the dynamic processes that drive SARS-CoV-2 transmission and advance intervention efforts to prevent COVID-19 morbidity and mortality, focusing on jails in North Carolina (NC). Specifically, a K01 award will provide substantive knowledge of the criminal justice system and infectious diseases in that context (Training Aim 1), methodological expertise in mathematical modeling of infectious disease dynamics (Training Aim 2), and new skills in linking system-level policy and interventions to epidemiological outcomes (Training Aim 3). Leveraging this training, Dr. Levintow will apply new expertise about infectious diseases in the criminal justice system to assess the extent to which population movement, COVID-19 testing, and COVID-19 cases in NC jails are predicted by jail characteristics (Research Aim 1). Guided by intensive training in the development, calibration, and analysis of mathematical models, Dr. Levintow will estimate SARS-CoV-2 incidence in NC jails and corresponding excess infection relative to surrounding communities (Research Aim 2). With new knowledge of existing and proposed interventions in jails – coupled with new skills to rigorously assess their effects – Dr. Levintow will evaluate the impact of those interventions on COVID-19 morbidity and mortality (Research Aim 3). Study findings will inform prioritization of interventions with greatest impact for the highly vulnerable populations in NC jails and their surrounding communities across the state. This study will benefit from the institutional resources of the University of North Carolina at Chapel Hill and will be guided by a mentoring team of leading experts with extensive experience examining infectious disease in the criminal justice system and conducting modeling analyses to inform interventions on spread of infection. This K01 award will provide both the training needed to accomplish the proposed research and the support necessary to launch Dr. Levintow's independence as an infectious disease epidemiologist, laying the groundwork for R01-level research expanded to the national level and to other infectious diseases with potential for explosive outbreaks in jails and prisons.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2024 ( Subtotal = $135,135 )
2024	2024	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Allergy and Infectious Diseases Research	000	3	7/17/2024	NON-COMPETING CONTINUATION	$135,135
														Subtotal = $135,135

Issue Date FY: 2023 ( Subtotal = $135,135 )
2023	2023	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Allergy and Infectious Diseases Research	000	2	7/20/2023	NON-COMPETING CONTINUATION	$135,135
														Subtotal = $135,135

Issue Date FY: 2022 ( Subtotal = $135,135 )
2022	2022	UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL	104 AIRPORT DR STE 2200	CHAPEL HILL	NC	27599	ORANGE	USA	Allergy and Infectious Diseases Research	000	1	8/22/2022	NEW	$135,135
														Subtotal = $135,135

Grand Total All Awards = $405,405

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Investigating SARS-CoV-2 transmission dynamics in jails to address the COVID-19 public health emergency

Award Number: K01AI171088

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 08/22/2022

PERIOD OF PERFORMANCE END DATE: 07/31/2027

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