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Nutritional Interventions to End Tuberculosis among persons with HIV in India (NUTRIENT-India)

Award Number: K01AI167733
ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 09/20/2023
PERIOD OF PERFORMANCE END DATE: 08/31/2028

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Nutritional Interventions to End Tuberculosis among persons with HIV in India (NUTRIENT-India) - PROJECT SUMMARY India has the third-highest number of persons with HIV. One-quarter of deaths among persons with HIV are due to TB. Undernutrition is the leading risk factor for TB in India. TB transmission from HIV-negative persons likely fuels the TB epidemic among Indian persons with HIV. I hypothesize that population-scale nutritional interventions would reduce TB incidence and mortality among persons with and without HIV. I also hypothesize that, in an Indian context, in-kind nutritional supplementation would be more cost-effective than cash transfers. Models allow us to generate representations of real-world problems in mathematical language which can be used to gain insights and to make projections. The proposed Nutritional Interventions to End Tuberculosis among persons with HIV in India (NUTRIENT-India) study will have the following aims: 1. Quantify the long-term impact of population-scale nutritional interventions on TB incidence and mortality among persons with and without HIV in the Indian state of Tamil Nadu using a microsimulation model 2. Estimate the impact and cost-effectiveness of a variety of nutritional interventions to decrease TB incidence & mortality among persons with and without HIV For aim 1, we will develop the microsimulation model and validate it. We will then calibrate the model using data from national health surveys and primary data from the ongoing TB Learning the Impact of Nutrition (LION) study of nutritional interventions. For aim 2, we will synthesize evidence on the impact of cash transfers and in-kind transfers on nutritional status of recipients. Next, we will adapt an existing Markov model to simulate three different nutritional interventions: 1) 2600 Kilocalories (Kcal)/d of food, 750 Kcal/d of food, and Rs 500/month cash transfer. We will obtain cost estimates from the TB-LION study and NTEP programmatic costs. After calibrating the model using data from TB-LION and the Regional Prospective Observational Research on Tuberculosis (RePORT)- India consortium, we will conduct cost-effectiveness analysis of the three different nutritional interventions. The NUTRIENT-India study will help quantify the long-term impact of nutritional interventions on TB incidence and mortality among persons with and without TB in India, The study will also define the most cost- effective nutritional interventions in the Indian context. Thus, it will inform policymakers on why they must address this critical TB risk factor that keeps TB entrenched in India and how they can intervene while making maximal use of available resources.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2025 ( Subtotal = $128,403 )
2025	2025	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL	BOSTON	MA	02118	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	3	9/8/2025	NON-COMPETING CONTINUATION	$128,403
														Subtotal = $128,403

Issue Date FY: 2024 ( Subtotal = $127,514 )
2024	2024	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL	BOSTON	MA	02118	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	2	8/7/2024	NON-COMPETING CONTINUATION	$127,514
														Subtotal = $127,514

Issue Date FY: 2023 ( Subtotal = $127,809 )
2023	2023	BOSTON MEDICAL CENTER CORPORATION	1 BOSTON MEDICAL CTR PL	BOSTON	MA	02118	SUFFOLK	USA	Allergy and Infectious Diseases Research	000	1	9/20/2023	NEW	$127,809
														Subtotal = $127,809

Grand Total All Awards = $383,726

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Nutritional Interventions to End Tuberculosis among persons with HIV in India (NUTRIENT-India)

Award Number: K01AI167733

ORGANIZATION: NATIONAL INSTITUTE OF ALLERGY & INFECTIOUS DISEASES

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 09/20/2023

PERIOD OF PERFORMANCE END DATE: 08/31/2028

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