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Insights into Cognitive Resilience: Sleep, Physical Activity, and Neuroimaging Biomarkers in Aging and Preclinical Alzheimer's Disease

Award Number: K01AG092954
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 06/15/2025
PERIOD OF PERFORMANCE END DATE: 03/31/2030

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Insights into Cognitive Resilience: Sleep, Physical Activity, and Neuroimaging Biomarkers in Aging and Preclinical Alzheimer's Disease - This Mentored Patient-Oriented Research Career Development Award (K01) application aims to equip the candidate with the skills to establish an independent research program identifying modifiable lifestyle factors to enhance cognitive resilience in aging and Alzheimer's disease-related dementias (ADRDs) and develop neuroimaging measures to quantify these relationships. The proposed research will examine (1) actigraphy- based measures of physical activity and sleep, and (2) network neuroimaging-based measures of functional connectivity and microstructural integrity, as potential synergistic correlates of cognitive trajectories in older adults and those with AD pathology accumulation. Recent published work by the candidate suggests physical activity and sleep are synergistically related to better cognition and neuroimaging measures of functional connectivity and microstructural integrity, and that these neuroimaging measures may reflect mechanisms of cognitive resilience in aging and AD cross sectionally. This application proposes a longitudinal study to assess i) whether physical activity and sleep are factors associated with cognitive resilience to AD pathology accumulation over time, ii) if brain network connectivity and microstructure are neuroimaging correlates of cognitive resilience to AD pathology over time, and iii) the association between physical activity and sleep with functional connectivity and microstructure over time. With an excellent multidisciplinary mentorship team, the applicants career development plan builds on his research training to gain experience in 1) AD pathology biomarkers (specifically Positron Emission Tomography and Cerebrospinal Fluid), 2) actigraphy based measures of physical activity and sleep, 3) longitudinal statistical analysis, 4) theoretical training in cognitive resilience research and clinical knowledge of AD and related disorders, 5) professional development, and 6) responsible conduct of research. The research objectives and training goals will foster an exceptional learning environment, advancing the candidate's knowledge in cognitive aging and ADRD, ultimately facilitating their transition to an independent investigator exploring the impact of modifiable lifestyle activities and brain mechanisms underlying cognitive resilience in older individuals.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $130,139 )
2026	2026	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	000	2	4/1/2026	NON-COMPETING CONTINUATION	$130,139
														Subtotal = $130,139

Issue Date FY: 2025 ( Subtotal = $129,659 )
2025	2025	THE JOHNS HOPKINS UNIVERSITY	3400 N CHARLES ST	BALTIMORE	MD	21218	BALTIMORE CITY	USA	Aging Research	000	1	6/9/2025	NEW	$129,659
														Subtotal = $129,659

Grand Total All Awards = $259,798

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Insights into Cognitive Resilience: Sleep, Physical Activity, and Neuroimaging Biomarkers in Aging and Preclinical Alzheimer's Disease

Award Number: K01AG092954

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 06/15/2025

PERIOD OF PERFORMANCE END DATE: 03/31/2030

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