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Exploring the impact of obesity on dementia/Alzheimer’s disease among older end-stage kidney disease patients

Award Number: K01AG092933
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/15/2026
PERIOD OF PERFORMANCE END DATE: 04/30/2031

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Exploring the impact of obesity on dementia/Alzheimer’s disease among older end-stage kidney disease patients - PROJECT SUMMARY/ABSTRACT 87% of older (≥55 years) adults with end-stage kidney disease (ESKD) have mild to severe cognitive impairment, resulting in a 21-25% lifetime risk of dementia/Alzheimer's disease (AD). The dementia/AD risk in older ESKD patients is elevated compared to community-dwelling older adults. Dementia/AD is associated with a 2-fold greater risk of ESKD mortality. Unlike in community-dwelling older adults for whom obesity is a risk factor for dementia/AD, in older ESKD patients obesity is associated with ~27% lower risk of dementia diagnosis. This is more evidence for the well-documented, but counter-intuitive, obesity paradox of dementia/AD in ESKD. The candidate has posited 3 methodologic explanations for this paradox: BMI is an imperfect measure of obesity that does not directly measure body composition; “diagnosed dementia/AD” is a simplified representation of the complexities of cognition and underestimates the true dementia/AD burden; and cognitive impairment may indirectly foster weight loss. The candidate will leverage an NIA-funded prospective R01 cohort of 2,700 ESKD patients, and conduct a pilot study at an obesity management clinic, to explore the ESKD obesity paradox of dementia/AD in ESKD and overcome methodological limitations of previous ESKD studies via the following aims: 1) Examine whether BMI, when augmented with novel anthropometric and body composition obesity measures, is associated with cognitive decline; 2) Test whether BMI, when augmented with novel anthropometric and body composition obesity measures, is associated with dementia/AD; and 3) Investigate whether intentional weight loss prevents cognitive decline. The candidate has designed a comprehensive training plan that includes in-depth coursework and clinical apprenticeship in dementia/AD and cognition, obesity management, and aging. This plan is supported by NYU Grossman School of Medicine, which provides ample research and training resources. The mentorship team includes expertise in aging, dementia/AD and cognition, obesity, biostatistics, nephrology, epidemiology, and radiology. This team will guide the candidate in meeting career goals; specifically, to become an independent investigator with expertise in obesity and cognitive aging in ESKD, to apply and obtain an NIA-funded R01 grant, and to improve outcomes of older ESKD patients. The study will explore the obesity paradox of dementia/AD in ESKD, and serve as the basis for developing obesity-related intervention strategies to reduce the risk of cognitive impairment for older ESKD patients. This study examines an NIA priority area (D-4): Effective treatment and/or prevention strategies for dementia/AD.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $137,245 )
2026	2026	NEW YORK UNIVERSITY	550 1ST AVE	NEW YORK	NY	10016	NEW YORK	USA	Aging Research	000	1	7/14/2026	NEW	$137,245
														Subtotal = $137,245

Grand Total All Awards = $137,245

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Exploring the impact of obesity on dementia/Alzheimer’s disease among older end-stage kidney disease patients

Award Number: K01AG092933

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/15/2026

PERIOD OF PERFORMANCE END DATE: 04/30/2031

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