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The role of 24-hour activity in Alzheimer's Disease

Award Number: K01AG083223
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 07/15/2023
PERIOD OF PERFORMANCE END DATE: 03/31/2028

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The role of 24-hour activity in Alzheimer's Disease - PROJECT SUMMARY. Alzheimer’s disease and related dementias (ADRD) has become a major public health crisis. To date, therapeutic strategies for Alzheimer’s disease have been largely ineffective resulting in an increased focus on identifying effective prevention strategies. Daily 24-hour activity behaviors (sleep, physical activity, and sedentary time) may be modifiable risk factors for ADRD. A better understanding of these risk factors may provide an opportunity for early prevention, particularly in the asymptomatic phase prior to the development of ADRD-related pathology. The availability of longitudinal actigraphy data to objectively-measure 24-hour activity in a strongly ADRD-phenotyped cohort has created the ideal opportunity to investigate potential pathways linking 24-hour activity behaviors with ADRD. The objective of this K01 is to longitudinally investigate changes in 24-hour activity with changes in cognition, structural neuroimaging, and fluid biomarkers of Alzheimer’s disease and concomitant pathological pathways prior to the onset of clinical dementia. I will leverage data from the Vanderbilt Memory and Aging Project (VMAP) cohort with repeated measures of actigraphy, brain MRI, and fluid biomarkers of Alzheimer’s disease neuropathology and concomitant injury. The central hypothesis of this proposal is changes in 24-hour activity will be associated with cognitive decline, structural neuroimaging changes, and Alzheimer’s disease and concomitant pathway changes, preceding symptom onset. Based on this hypothesis, the proposal aims to 1) characterize associations between changes in 24-hour activity and cognitive decline, 2) examine changes in 24-hour activity in relation to MRI markers of neurodegeneration and small vessel disease, and 3) evaluate changes in 24-hour activity behaviors with fluid biomarkers of Alzheimer’s disease neuropathology and concomitant pathways. Taken together, these aims will combine objective measurement of 24-hour activity with cognitive, neuroimaging, and state of the art fluid biomarker data to fill existing gaps in the research. Simultaneously, throughout the award, the candidate will gain advanced training in 1) Alzheimer’s disease pathophysiology and epidemiology; 2) measurement and modeling of structural imaging and fluid biomarkers of Alzheimer’s neuropathology and concomitant pathways of injury; and 3) advanced statistical methods, positioning the candidate to become a leader in the fields of aging and Alzheimer’s disease epidemiology. Vanderbilt University Medical Center and the Vanderbilt Memory and Alzheimer’s Center provide the ideal environment to complete the proposed research and training activities. The overall goal of this K01 is to inform a series of R01 awards and independent research program focused on identifying and characterizing behavioral risk factors for ADRD. With the support of this K01 award and expert mentorship, the candidate will achieve this goal and successfully transition to independent investigator status by the conclusion of the training period.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $120,177 )
2026	2026	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	000	4	2/26/2026	NON-COMPETING CONTINUATION	$120,177
														Subtotal = $120,177

Issue Date FY: 2025 ( Subtotal = $120,177 )
2025	2025	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	000	3	5/20/2025	NON-COMPETING CONTINUATION	$120,177
														Subtotal = $120,177

Issue Date FY: 2024 ( Subtotal = $120,177 )
2024	2024	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	000	2	5/14/2024	NON-COMPETING CONTINUATION	$120,177
														Subtotal = $120,177

Issue Date FY: 2023 ( Subtotal = $120,177 )
2023	2023	VANDERBILT UNIVERSITY MEDICAL CENTER	1161 21ST AVE S STE D3300 MCN	NASHVILLE	TN	37232	DAVIDSON	USA	Aging Research	000	1	7/14/2023	NEW	$120,177
														Subtotal = $120,177

Grand Total All Awards = $480,708

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The role of 24-hour activity in Alzheimer's Disease

Award Number: K01AG083223

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 07/15/2023

PERIOD OF PERFORMANCE END DATE: 03/31/2028

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