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Heart-brain MRI for the evaluation of hemodynamic coupling in aging and Alzheimer's disease

Award Number: K01AG080070
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP
PERIOD OF PERFORMANCE START DATE: 01/01/2023
PERIOD OF PERFORMANCE END DATE: 12/31/2027

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Heart-brain MRI for the evaluation of hemodynamic coupling in aging and Alzheimer's disease - Project Summary/Abstract Cardiovascular risk factors have been implicated in Alzheimer's disease and related dementias, however, mechanisms underlying heart-brain hemodynamic coupling are not well understood. Aortic stiffening has been associated with increased dementia risk. In addition to brain changes typically associated with aging, cerebrovascular disease and Alzheimer's disease also affect vascular function and neuronal structure. However, the heart and brain are not usually evaluated in the same MRI exam, rather, in separate scanning sessions with highly specialized protocols focused on either cardiovascular or brain imaging. Recently, our group and others have established advanced MRI techniques to capture measures such as cardio- and cerebrovascular hemodynamics and brain structure in the same MRI exam. Measuring aortic hemodynamics (e.g., pulse wave velocity), together with intracranial pulsatility and brain abnormalities associated with cerebrovascular disease and Alzheimer's disease, will provide critical insights concerning underlying hemodynamic mechanisms. The proposed research will use advanced MRI techniques for comprehensive analysis of heart-brain hemodynamic coupling. This project will leverage new developments in cardiovascular imaging, particularly using 4D flow MRI, that enable full characterization of complex 3D hemodynamics, such as blood flow velocity, reverse flow mapping and aortic pulse wave velocity. Methodological advances in highly accelerated 4D flow MRI enable integration of cardiovascular and intracranial 4D flow MRI with quantitative structural analysis of the brain in a single MRI exam. This combined cardio- and cerebrovascular 4D flow MRI with quantitative brain imaging (i.e. “heart-brain MRI”) will be used to analyze hemodynamic coupling in aging and Alzheimer's disease. The goal of this proposal is to use novel heart-brain MRI to systematically evaluate hemodynamic coupling relationships in normal aging, and hypertension, and apply this technique in a pilot study of Alzheimer's disease. In Aims 1 and 2, heart-brain MRI will be evaluated in healthy adults and those with hypertension at both midlife and later life, to determine relationships between heart-brain MRI measures in normal aging and how hypertension may exacerbate brain changes with aging. In Aim 3, heart-brain MRI will be applied in a pilot study of Alzheimer's disease to examine preliminary relationships and help plan future studies. This K01 will provided training in clinical and neuroimaging aspects of aging and Alzheimer's disease to further the objective of building an independent research program focused on heart-brain hemodynamic coupling in cognitive aging and dementia, including that caused by Alzheimer's disease.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $124,065 )
2026	2026	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Aging Research	000	4	1/21/2026	NON-COMPETING CONTINUATION	$124,065
														Subtotal = $124,065

Issue Date FY: 2025 ( Subtotal = $124,055 )
2025	2025	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Aging Research	000	3	11/21/2024	NON-COMPETING CONTINUATION	$124,055
														Subtotal = $124,055

Issue Date FY: 2024 ( Subtotal = $124,065 )
2024	2024	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Aging Research	000	2	1/10/2024	NON-COMPETING CONTINUATION	$124,065
														Subtotal = $124,065

Issue Date FY: 2023 ( Subtotal = $124,055 )
2023	2023	NORTHWESTERN UNIVERSITY	633 CLARK ST	EVANSTON	IL	60208	COOK	USA	Aging Research	000	1	12/16/2022	NEW	$124,055
														Subtotal = $124,055

Grand Total All Awards = $496,240

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Heart-brain MRI for the evaluation of hemodynamic coupling in aging and Alzheimer's disease

Award Number: K01AG080070

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

PERIOD OF PERFORMANCE START DATE: 01/01/2023

PERIOD OF PERFORMANCE END DATE: 12/31/2027

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