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The Epidemiology of Alzheimer's Disease and Related Dementias in Sexual and Gender Minority Older Adults: Identifying Risk and Protective Factors

Award Number: K01AG056669
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

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Abstract By 2030, there will be nearly six million sexual and gender minority (SGM) older adults aged 60 and older in the U.S. who identify as lesbian, gay, bisexual and transgender. Approximately 350,000 SGM older adults in the U.S. currently have Alzheimer’s disease and related dementias (ADRD), with projections nearing one million by 2030. Yet, almost nothing is known about the prevalence or risk of ADRD in SGM older adults without HIV/AIDS. This proposal will focus on the epidemiology and risk of ADRD in SGM older adults. The first aim of this proposal is to characterize the epidemiology and risk of ADRD in a population-based sample of SGM older adults and compare the prevalence and incidence of ADRD in SGM older adults to their heterosexual peers. The second aim will focus on identifying risk and protective factors for ADRD in SGM older adults, and to estimate the population attributable risk of depression and socioeconomic status (e.g., income and education) on ADRD. The third aim will involve primary data collection in a community-based sample of SGM older adults in order to investigate the relationship between risk and protective factors and cognition, including memory and executive function. This proposal incorporates several innovations that will allow me to evaluate the epidemiology and risk of cognitive impairment and ADRD in SGM older adults: 1) this will be the first study of the epidemiology and associated risk and protective factors for cognitive impairment and ADRD in SGM older adults; 2) it leverages the largest longitudinal dataset in the nation, Research Program for Genes Environment and Health (RPGEH), with data on the physical and psychosocial health of SGM older adults; and 3) it involves a novel investigation of factors that may be associated with memory and executive function impairment in SGM older adults. To successfully complete this research, I propose three training aims: 1) advanced statistical modeling of ADRD risk and protective factors; 2) epidemiology of SGM aging and health disparities; and 3) measurement and analysis of cognitive aging. This career development award ultimately will result in the submission of a R01 to develop a future multi-site epidemiological study of cognitive aging and ADRD in SGM older adults. Given that nothing is currently known about ADRD risk in this population, this work is necessary to promote early detection; to develop culturally relevant screenings and targeted preventative interventions to decrease ADRD risk in SGM older adults; and to improve the care and quality of life of this vulnerable and understudied population.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2022 ( Subtotal = $126,738 )
2022	2022	BOARD OF REGENTS NEVADA SYSTEM OF HIGHER EDUCATION	4505 S MARYLAND PKWY	LAS VEGAS	NV	89154	CLARK	USA	Aging Research	000	5	7/13/2022	NON-COMPETING CONTINUATION	$126,738
														Subtotal = $126,738

Issue Date FY: 2021 ( Subtotal = $126,738 )
2021	2021	BOARD OF REGENTS NEVADA SYSTEM OF HIGHER EDUCATION	4505 S MARYLAND PKWY	LAS VEGAS	NV	89154	CLARK	USA	Aging Research	002	4	7/13/2021	NON-COMPETING CONTINUATION	$126,738
2021	2020	BOARD OF REGENTS NEVADA SYSTEM OF HIGHER EDUCATION	4505 S MARYLAND PKWY	LAS VEGAS	NV	89154	CLARK	USA	Aging Research	001	3	11/9/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$87,491
2021	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	2	11/9/2020	NON-COMPETING CONTINUATION	-$87,491
														Subtotal = $126,738

Issue Date FY: 2020 ( Subtotal = $126,738 )
2020	2020	BOARD OF REGENTS NEVADA SYSTEM OF HIGHER EDUCATION	4505 S MARYLAND PKWY	LAS VEGAS	NV	89154	CLARK	USA	Aging Research	001	3	7/29/2020	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$126,738
2020	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	2	7/24/2020	NON-COMPETING CONTINUATION	$0
														Subtotal = $126,738

Issue Date FY: 2019 ( Subtotal = $142,974 )
2019	2019	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94143	SAN FRANCISCO	USA	Aging Research	000	2	7/3/2019	NON-COMPETING CONTINUATION	$142,974
														Subtotal = $142,974

Issue Date FY: 2018 ( Subtotal = $142,974 )
2018	2018	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 420	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Aging Research	000	1	8/3/2018	NEW	$142,974
														Subtotal = $142,974

Grand Total All Awards = $666,162

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The Epidemiology of Alzheimer's Disease and Related Dementias in Sexual and Gender Minority Older Adults: Identifying Risk and Protective Factors

Award Number: K01AG056669

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: TRAINING/TRAINEESHIP

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