Tuesday, February 17, 2026 2/17/2026

USING DEEP MUTATIONAL SCANNING TO CHARACTERIZE TUMOR-IMMUNE INTERACTIONS

Award Number: K00CA264307
ORGANIZATION: NATIONAL CANCER INSTITUTE
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 01/01/2025
PERIOD OF PERFORMANCE END DATE: 12/31/2028

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USING DEEP MUTATIONAL SCANNING TO CHARACTERIZE TUMOR-IMMUNE INTERACTIONS - Cancer immunotherapy is a new treatment modality that has revolutionized cancer care, providing benefits to many patients who previously had untreatable disease. However, we still do not fully understand how this breakthrough treatment works at a molecular level. Deep mutational scanning (OMS) is a new technique that enables the generation of large-scale libraries of mutants to understand how changes at the sequence level impact downstream protein phenotypes. Unlike previous, targeted mutagenesis techniques which were limited in the number of mutants that could be surveyed, OMS is capable of generating a comprehensive map of all potential amino acid change in a given protein. I will use OMS to profile how alterations to PD1, one of the key targets of cancer immunotherapy, impact myeloid cell function. A key limitation of existing OMS assays is the relatively coarse readouts, such as cell proliferation. In order to generate a richer characterization of each OMS mutant, I will couple it to single-cell RNA sequencing to enable fine grained readouts of cell state. I will then use the resulting data to train a large language model (LLM), a type of mathematical model that is capable of predicting the impacts of immunotherapy on cell state. This fellowship will give me the tools and techniques to advance my career, launching me on the path to becoming an independent investigator at an R 1 institution.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = $87,917 )
2026	2026	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cancer Cause and Prevention Research	000	4	1/21/2026	NON-COMPETING CONTINUATION	$87,917
														Subtotal = $87,917

Issue Date FY: 2025 ( Subtotal = $94,091 )
2025	2025	REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE	1855 FOLSOM ST STE 425	SAN FRANCISCO	CA	94103	SAN FRANCISCO	USA	Cancer Cause and Prevention Research	000	3	12/4/2024	EXTENSION WITH OR WITHOUT FUNDS	$94,091
														Subtotal = $94,091

Grand Total All Awards = $182,008

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USING DEEP MUTATIONAL SCANNING TO CHARACTERIZE TUMOR-IMMUNE INTERACTIONS

Award Number: K00CA264307

ORGANIZATION: NATIONAL CANCER INSTITUTE

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 01/01/2025

PERIOD OF PERFORMANCE END DATE: 12/31/2028

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