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Neurovascular Contributions to Cognitive and Mental health in Older Adult Critical Care Survivors

Award Number: K00AG090127
ORGANIZATION: NATIONAL INSTITUTE ON AGING
OPDIV: NIH
AWARD CLASS: DISCRETIONARY
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
PERIOD OF PERFORMANCE START DATE: 09/01/2021
PERIOD OF PERFORMANCE END DATE: 07/31/2025
AWARD TERMINATION DATE: 05/28/2025

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Neurovascular Contributions to Cognitive and Mental health in Older Adult Critical Care Survivors - ABSTRACT/SUMMARY: Patients who survive an Intensive Care Unit (ICU) hospitalization will likely experience new or worsened physical, mental, and/or cognitive impairments (termed Post-Intensive Care Syndrome (PICS)). The most vulnerable to long-term physical and cognitive impairments are older adults (>60 y) because of pre-existing age-related physical frailty or cognitive frailty. Both of which increase a survivor’s likelihood of developing Alzheimer’s diseases and related dementias. However, although advances in critical care treatments have reduced mortality rates among older adult ICU survivors, roughly 67% suffer PICS. Yet, identification of at-risk older adults during admittance is likely difficult because of the 1) homogeneity in the clinical presentation of patients with pre-existing age-related physical frailty and critical illness compared to those suffering from only critical illness and 2) many patients arrive severely debilitated making administration of physical function or other volitional assessments difficult. Therefore, it is essential that new biomarkers to guide early diagnosis, prognosis, and disease monitoring are identified. To this point, tryptophan derivatives, particularly kynurenines and nicotinamide family (e.g., NAD+), have been shown to mediate the relationship between chronic inflammation and physical impairment or signal accelerated aging, respectively. However, it remains unknown if similar associations exist in older adult ICU patients and the prognostic utility of elevated neurotoxic tryptophan metabolites relative to neuroprotective tryptophan metabolites to predict adverse health outcomes while in the ICU. Thus, to fill this knowledge gap I have design three studies to explore the associations between tryptophan derivatives, musculoskeletal health, and cognitive function pre-, intra-, and post-ICU stay. Skills gained during this fellowship will provide be a better understanding of frailty and muscle-brain crosstalk, via the kynurenine pathway, that occurs during an ICU stay and how it may influence long-term physical and cognitive health.


Issue Date FY	Funding FY	Legal Entity Name	Legal Entity Address	Legal Entity City	Legal Entity State	Legal Entity Zip Code	Legal Entity COUNTY	Legal Entity COUNTRY	Assistance Listing	Award Code	Budget Year	Action Date	Action Type	Action Amount

Issue Date FY: 2026 ( Subtotal = -$1,241 )
2026	2024	THE SPAULDING REHABILITATION HOSPITAL CORPORATION	300 1ST AVE	CHARLESTOWN	MA	02129	SUFFOLK	USA	Aging Research	000	3	1/8/2026	TERMINATION	-$1,241
														Subtotal = -$1,241

Issue Date FY: 2025 ( Subtotal = $0 )
2025	2024	THE SPAULDING REHABILITATION HOSPITAL CORPORATION	300 1ST AVE	CHARLESTOWN	MA	02129	SUFFOLK	USA	Aging Research	000	3	5/28/2025	TERMINATION	$0
														Subtotal = $0

Issue Date FY: 2024 ( Subtotal = $91,152 )
2024	2024	THE SPAULDING REHABILITATION HOSPITAL CORPORATION	300 1ST AVE	CHARLESTOWN	MA	02129	SUFFOLK	USA	Aging Research	000	3	8/13/2024	CHANGE OF GRANTEE / TRAINING INSTITUTION / AWARDING INSTITUTION	$91,152
														Subtotal = $91,152

Grand Total All Awards = $89,911

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Neurovascular Contributions to Cognitive and Mental health in Older Adult Critical Care Survivors

Award Number: K00AG090127

ORGANIZATION: NATIONAL INSTITUTE ON AGING

OPDIV: NIH

AWARD CLASS: DISCRETIONARY

AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)

PERIOD OF PERFORMANCE START DATE: 09/01/2021

PERIOD OF PERFORMANCE END DATE: 07/31/2025

AWARD TERMINATION DATE: 05/28/2025

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