Centerstone’s Treatment and Recovery Services (C-TRS) - Centerstone’s Treatment and Recovery Services (C-TRS) will enhance and expand treatment, early intervention, and recovery support services in 7 Indiana counties (Bartholomew, Delaware, Johnson, Madison, Morgan, Union, Wayne) for 345 unduplicated youth (ages 12-17) and young adults (YA) (ages 18-25), and their families/primary caregivers with substance use disorders (SUD) and/or co-occurring substance use and mental disorders (COD) (Yr 1: 25; Yrs 2- 5: 80/yr.). Focus population demographics are expected to mirror those of the catchment area’s 119,000+ youth and YA, comprising 51% male, 49% female, 84% White, 5% African American, and 4% Hispanic/Latino individuals. Subpopulations include the estimated 19,240 of the focus population who are Hispanic/Latino; 58,680 (49%) females ages 12-25; 1,630 who are systems involved youth (e.g., foster care, juvenile justice); and Veterans ages 18-25 (190) and/or Veteran households with children (1,000). An estimated 1,705 youth ages 12-17 and 10,455 YA ages 18-25 are expected to have SUD; 850 youth and 5,290 young adults are expected to have COD. The COD rate of young adults is greater than that of adolescents’ (7.6% vs. 1.7%). System-involved youth/young adults have a significantly higher prevalence of SUD (40% juvenile justice; 35% foster care). Half (17,745) of area young women ages 18-25 are expected to have SUD or AMI. Of Veterans ages 18-25, an estimated 9% (57) have an SUD, and 21% (133) have Alcohol Use Disorder, more than double Veterans ages 26-54 (10%) and 5 times Veterans ages 55+ (4%). Hispanic/Latinos are less likely to receive substance abuse treatment compared to whites (93% vs. 86%), C-TRS will implement project strategies/interventions within a Recovery-Oriented System of Care (ROSC), delivering evidence-based Matrix, Medication Assisted Treatment, Seeking Safety, Recovery Housing, and SAMHSA’s Implementing Tobacco Cessation Programs in SUD Treatment Settings, according to participants’ needs. C-TRS’ goals include: Enhancing/expanding evidence-based and family-centered SUD/COD treatment, including non-traditional hours and related recovery/support/education services; implementing a project to provide screening, assessment, treatment, wraparound, and recovery support services in an integrated outpatient/intensive outpatient/day treatment setting for youth/YA with SUD and COD and their families/primary caregivers; improving clients’ health status/outcomes; and developing/disseminating a replicable service model. C-TRS will achieve measurable objectives related to key activities including providing education to 1,000 youth/YA/families on making healthy choices; providing education to 1,000 persons on MOUD, MAUD, OD prevention, naloxone and other opioid OD reversal medications; conducting outreach to 450 stakeholders; and providing comprehensive treatment to 345 youth/YA and their families/caregivers. Among participants, C-TRS will increase substance use abstinence among 40% youth/YA; reduce mental health symptomatology by 50% for youth/YA with COD; increase service access by 90%; reduce tobacco use by 30%; improve family functioning among 60% of families; decrease risk factors by 50%; and achieve 80% participant retention. C-TRS has secured agreements from community collaborators dedicated to the project’s success and will maintain collaboration with youth-serving organizations, providers, and other key community stakeholders throughout the grant.