Decades of practice-to-science efforts have sought to improve prevention and harm reduction efforts within local communities to effectively address the co-occurring mental health, substance use and sexual health needs of under-served and under-resourced youth populations and thwart the growing health disparities. To date, the use of evidence based approaches that integrate substance use, mental health and sexual health related prevention and harm reduction efforts using a prevention navigation SBIRT practice model in local community health settings is greatly lacking. Prevention Navigation has received considerable attention among researchers, clinicians, and policy makers as a promising strategy to help such service gaps within settings and access issues to integrated services. In response to SAMHSA NOFO TI-24-005, a collaborative team from Azusa Pacific University (APU), Maryvale, and Bienestar will implement Project Youth Wellness using a Prevention Navigation Approach for increasing Community Capacity to address co-occurring substance use, mental health and sexual health risk issues among under-served youth populations aged 12-24 in a local community of Los Angeles County called San Gabriel valley, Service Planning Area (SPA) 3.