NATIVE HEALTH is proposing to implement a pilot project that will reach the urban Indigenous, Hispanic, and other underserved and minority populations in Maricopa County. We aim to engage 600 unduplicated participants per year and over the course of five year will have reached 3,000 participants. The agency will implement a robust low-barrier, trauma-informed HIV/HCV/STI and SUD prevention and treatment program centering around opioid use prevention and treatment, rapid testing, initiation to PrEP/PEP, and harm reduction services. Through this program the agency will deploy peer support services and wrap around case management services to improve adherence rates and recovery rates. A robust program evaluation will ensure fidelity to the best practices and performance monitoring over the lifetime of the project.