The Gila River Indian Community (GRIC), is a federally recognized tribe and the population of the focus for the proposed Tribal Opioid Response Project are youth (ages 14-17) and adults who are GRIC members and/or AI/AN members residing in the community. The proposed catchment area for the Tribal Opioid Response Project is the GRIC located on 372,000 acres of land south of the Phoenix Metropolitan area in both Pinal and Maricopa Counties. The tribal membership includes both the Akimel O’odham (Pima) and Pee-Posh (Maricopa) people. The project will be successfully implemented under the guidance and management of the Gila River Health Care (GRHC). The focus of this project includes, (1) enhancing community partner collaborations between specific community departments to identify community members needing treatment and/or recovery support, (2) advance current prevention programming efforts through community awareness and education campaigns; (3) increase treatment efforts with Medication Assisted Treatment (MAT)/Medication for Opioid Use Disorder (MOUD), (4) develop infrastructure to implement contingency management for stimulant use disorder, (5) enhance the avenue for recovery support/sober living housing. The current Indian Health Service User Population for GRIC is 36,175. Of the population, it is estimated 8,642 (37.7%) do not reside within the boundaries of the community. Arizona Department Health Services (ADHS) reported in the 2020 Primary Care Area Statistical Profile estimated the population to be 14,260 (residing in GRIC).1 GRHC will design the collaborative coalition of partners to oversee the progress of the program and regularly evaluate program data. This will be implemented under the support of a key stakeholder coalition which is approximately ten members of Gila River Health Care Behavioral Health Services Prevention and Treatment teams, GRIC Department of Rehabilitation Services, GRIC Police Department, GRIC Tribal Social Services, GRIC Tribal Health Department and other community representatives.