Center for Health Justice proposes to implement Project Hope in the priority jurisdiction of Los Angeles County (LAC) to reach 18–35-year-old justice-impacted Latinx and Black/African American (B/AA) men and women, including those identified as Lesbian, Gay, Bisexual, Transgender, Queer, Intersex, Asexual, and Two-Spirited (LGBTQIA2S+) communities with substance use disorders (SUDs) and/or co-occurring SUDs and mental health conditions (COD) who are at risk for or living with HIV. Project Hope’s catchment area will cover the Metro and South region of LAC and provide services to individuals being released from the LAC Men’s Central Jail located in Downtown Los Angeles, California. Project Hope will screen 1,000 (Y1: 125, Y2-Y4: 250, Y5: 125) adults transitioning from incarceration to community or on parole for HIV testing, as well as provide on-site or linkage to confirmatory HIV testing for individuals that test positive. Project Hope will enroll 375 (Y1-Y5: 75) into appropriate SUD and/or COD person-centered treatment and recovery support services. Project Hope will use Motivational Interviewing and Living in Balance as the interventions to address SUD and/or COD.