The overarching goal of the South Carolina (SC) State Pilot Program for Treatment for Pregnant and Postpartum Women (PPW-PLT) is the reduce maternal morbidity and morality associated with Perinatal Mental Health (PMH) and Perinatal Substance Use Disorder (PSUD), including Perinatal Opioid Use Disorder (POUD) by addressing gaps in the continuum of care throughout pregnancy and the postpartum year for the mother-infant dyad and family unit. The pilot program will build upon an existing statewide initiative, Moms IMPACTT (Improving Access to Perinatal Mental Health and Substance Use Disorder Care Through Telehealth and Tele-mentoring), which provides immediate access to treatment and care coordination via phone and telehealth modalities for POUD and PSUD/PMH concerns. The proposed project will allow our team to leverage and expand the IMPACTT program to include: 1) access to POUD treatment for PPW 7 days a week, including Medications for Opioid Use Disorder (MOUD); 2) addition for Doula-Certified Peer Support Specialists (DCPSS) to enhance treatment engagement and family-based service delivery and recovery support during pregnancy and the postpartum year; 3) intensive case management for families with minor children to facilitate immediate access to mental health assessment and treatment via telehealth; 4) strategic collaboration with community and public agencies (i.e., community mental health, family recovery support, healthy start, schools, child protection and foster care service systems); and 5) expanded outreach to obstetric and pediatric clinics, FQHCs, detention centers, family shelters, harm reduction services and community-based organizations in SC counties with the highest rates of NAS and opioid overdose. Mom's IMPACTT also provides frontline provider training and provider-to-provider consultations, which will be increased to 7 days a week, with expanded outreach as described above, and include hospitals, emergency departments and law enforcement in counties with the highest rates of NAS and opioid overdose. The geographic catchment area where services will be delivered are counties in SC with highest rates of Neonatal Abstinence Syndrome (NAS) and opioid overdose (Charleston, Horry and Lexington), and those designated as fully rural, fully Medically Underserved Areas, fully Mental Health and Health Professional Shortage Areas, and high proportion of women living below poverty: Chesterfield (33% African American [AA]; 21% Below Poverty [BP], Darlington (42% AA; 24% BP), Dillon (47% AA; 32% BP), Jasper (37.8% Black; 16.1% BP), Lancaster (20.8%; 11.8% BP) and Orangeburg (61.8% Black; 25.6% BP). Outcomes include improved treatment attendance, engagement and retention, depression symptoms and maternal functioning, birth outcomes, Social Determinants of Health, child/parent attachment, and increased number of Plans of Safe Care among perinatal women accessing the program. MOMs IMPACTT will serve a minimum of 50 women with PSUD/PMH concerns in the first year and increase the number served by 15% each year of the award. Additionally, it is projected that 112 unduplicated women will be provided access to a DCPSS throughout the project period: year 1 (18), year 2 (38), and year 3 (56). Infrastructure activities will leverage current work being done across SC, including an enhanced current needs assessment and statewide strategic plan to pinpoint gaps in the continuum of care for PPW and their families.