The Illinois Department of Human Services, Division of Substance Use Prevention and Recovery (IDHS/SUPR), submits this application in response to SAMHSA FOA # TI-22-005, SOR-III. Through this SOR-III grant, IDHS/SUPR will provide a comprehensive array of SUD evidence-based prevention, treatment, harm reduction and recovery support services that build upon the knowledge and learnings gained through previous SOR grants. Evidence of the multiple impacts of the opioid and stimulant crisis among Illinois residents is provided in the population of focus and needs assessment. Evidence of increased primary opioid clients among IDHS/SUPR-funded treatment admissions, increased need for medication for Opioid Use Disorder (MOUD) for persons with opioid use disorder (OUD), increasing numbers of opioid overdose deaths and poly-substance deaths, increasing numbers of persons using methamphetamines and other stimulants, and increasing numbers of opioid-related overdose reversals. A strategic plan, needs assessment and naloxone saturation plan are attached. The services supported and expanded through this SOR grant include: MAR-NOW, 24/7 treatment referrals and connection to care in the community; National Assn. of Recovery Residences best practices and capacity expansion; Recovery Community Organization (RCO) expansion to include recovery support services including coaching, vocational training, employment supports, transportation, and childcare. RCOs will also increase their capacity to provide housing supports including application fees, deposits, rental assistance, utility deposits and utility assistance. certification training on the Community Reinforcement Approach and Contingency Management; community-based linkage and referral services provided by peer outreach workers; SUD Leadership Centers to disseminate expertise in stigma reduction, rural health, community capacity building; access to MOUD Hub and Spoke services; SUD services in the healthcare system including SBIRT; integration and increased MOUD services provided by Federally Qualified Health Centers; MOUD integration for criminal justice-involved populations; housing stabilization for persons with OUD; enhanced treatment services for pregnant and postpartum women with OUD; recovery housing services for persons with OUD; enhancements to the Illinois Prescription Monitoring Program (PMP); and, expansion of the Illinois Opioid Helpline. The prevention services that are proposed include: Naloxone purchase, overdose education, training, and distribution services in counties of high need, through OTPs and through our naloxone saturation plan; Illinois prevention provider contracts to support implementation of the OUD-focused program for adolescents; and, expansion of our statewide opioid awareness campaign. A data collection plan is provided that describes data collection, management, analysis, and reporting in response to federal requirements. This includes administration of the SAMHSA/CSAT GPRA tool to our unduplicated count of at least 6,000 persons served over the two years of funding at admission, six-month follow-up, and at discharge from services, and refresher training of all providers. A process and outcome performance measurement plan will be implemented online through the REDcap web application. The organizational experience, resources, and qualifications of IDHS/SUPR and our major partner organizations are described. Biographical sketches for the Illinois SSA, the Project Director, the Project Coordinator, and other grant staff are provided. A line-item budget and narrative justification is proposed for $37,187,828 for each of the two years of this SAMHSA funding opportunity.