The Delaware Division of Substance Abuse and Mental Health's (DSAMH) State Opioid Response (SOR) project is a statewide initiative that will enhance and further develop the opioid and stimulant use disorder (OUD/STUD) system of care for all Delawareans while dedicating focused efforts on six key populations: pregnant and parenting people, racial/ethnic minorities, individuals in high-need zip codes (including rural), LGBTQ+ populations, justice-involved populations, and school-aged youth. Building on efforts in SOR 2, DSAMH and its partners will: (1) enhance structures and processes to oversee and administer grant activities; (2) establish a centralized data-responsive strategy and hub (the "Opioid Response Center" or ORC); (3) increase the availability, quality, and sustainability of evidence-based treatment and recovery services, with a focus on low-barrier, rapid-access to Medications for Opioid Use Disorder (MOUD) and contingency management programming; (4) effectively collaborate with other systems and entities, as well as the public, to facilitate OUD/STUD prevention, harm reduction practices, and seamless pathways into OUD/STUD treatment and recovery services; (5) support new and existing partners to proficiently implement evidence-based and data-responsive practices to improve the engagement, care, and outcomes of under-served populations; and (6) implement recovery support services that facilitate pathways to long-term recovery, address social needs, and promote quality of life.