New Mexico is positioned to address the opioid use disorder (OUD) crisis through implementation of evidence-based practices (EBPs) in prevention, treatment, recovery and harm reduction through use of the SOR 3 funds. The New Mexico State Opioid Response 3 (NMSOR3) grant will continue to expand capacity to address OUD morbidity and mortality via the modified Hub and Spoke model (Collaborative Hubs Model) to support the adoption and implementation of EBPs statewide that have proven effectiveness to prevent, treat, support recovery and reduce harm related to OUD. NMSOR3 will support services across a broad range of ages, and cultural and ethnic groups, including Native American communities and Hispanic populations. The overarching goal of NMSOR3 is to reduce OUD rates and overdose deaths. To accomplish this, NMSOR3 has the following specific goals: (1) Increase access to medication-assisted treatment (MAT) using three FDA-approved medications for the treatment of OUD; (2) Ensure MAT is comprehensive and includes FDA approved medications, therapy, and recovery supports; (3) Expand access to recovery services, including peer supports; (4) Expand access to evidence-based prevention activities; (5) Expand tribal focused opioid use disorder education efforts; and (6) Ensure continuous quality improvement through quality data collection, reporting & evaluation. We will accomplish these goals by expanding upon the NM Collaborative Hubs approach. Collaborative Hub partners will provide: comprehensive MAT services for persons with OUD; evidence based prevention services in primary and secondary schools; awareness and engagement in MAT using a statewide media campaign; training in use of naloxone for harm reduction and engagement of survivors of overdose in MAT (buprenorphine and methadone treatments); training and support to health care workforce (primary care, behavioral health, recovery), first responders on use of naloxone to help reverse overdose; and training in all components of MAT including prescribing of FDA approved medications, psychosocial supports (e.g. Motivational Interviewing, Community Reinforcement Approach, CRAFT) and recovery supports with a focus on expansion of peer recovery services. The GPRA tool will be collected on all individuals receiving treatment and recovery services with 500 persons reached annually, and 1000 persons over the life of the 2-year grant. Prevention numbers served are 50,000 annually (100,00 over the life of the grant).